Gainers

Find out what's going on in today's market and bring any questions you have to Benzinga's PreMarket Prep.

Check out these big penny stock gainers and losers

Losers

• Avenue Therapeutics, Inc. (NASDAQ:ATXI) fell 18.4% to $5.80 in pre-market trading as the company said the FDA is still reviewing its NDA resubmission for IV Tramadol and has not provided decision.
• Fortress Biotech, Inc. (NASDAQ:FBIO) fell 13.9% to $4.72 in pre-market trading. Fortress Biotech recently received a $7.5 million working capital line of credit.
• Odonate Therapeutics, Inc. (NASDAQ:ODT) fell 8% to $3.24 in pre-market trading after declining around 9% on Monday.
• Akari Therapeutics, Plc(NASDAQ:AKTX) fell 7.5% to $2.10 in pre-market trading. On Monday, the FDA opened the investigational new drug application for Phase 3 trial for Akari Therapeutics lead drug candidate, nomacopan, for the treatment of moderate and severe Bullous Pemphigoid (BP), allowing clinical sites to open mid-2021, subject to the ongoing impact of COVID related restrictions.
• MoSys, Inc. (NASDAQ:MOSY) fell 7% to $3.84 in pre-market trading. MoSys shares gained over 10% on Monday after the company announced it has expanded its patent portfolio through the purchase of five patents in the area of search and classification algorithms..
• Unico American Corporation (NASDAQ:UNAM) fell 6.2% to $5.00 in pre-market trading after dropping 7% on Monday.