Gainers

  • Microbot Medical Inc MBOT shares rose 12.8 percent to $2.38 in pre-market trading after the company disclosed that the United States Patent and Trademark Office granted patent for a device for preventing shunt stenosis.
  • DryShips Inc. DRYS shares rose 12.8 percent to $2.20 in the pre-market trading session after gaining 4.84 percent on Tuesday.
  • Zynerba Pharmaceuticals Inc ZYNE shares rose 11.8 percent to $20.00 in pre-market trading after climbing 7.71 percent on Tuesday.
  • H & R Block Inc HRB rose 10.6 percent to $29.85 in pre-market trading after the company reported stronger-than-expected earnings for its fourth quarter and raised its quarterly dividend to $0.24 per share.
  • Brookdale Senior Living, Inc. BKD rose 10.2 percent to $15.50 in pre-market trading after Reuters reported Tuesday that Zhonghong Zhuoye Group is in talks to buy the company.
  • BioTime, Inc. BTX shares rose 9.2 percent to $3.69 in pre-market trading after gaining 6.96 percent on Tuesday.
  • ReneSola Ltd. (ADR) SOL rose 8.4 percent to $2.59 in pre-market trading after the company announced an offer from the company's CEO to acquire the manufacturing business for assumption of debt.
  • Alexion Pharmaceuticals, Inc. ALXN shares rose 4.4 percent to $112.78 in pre-market trading after the company named Paul Clancy as its new CFO on Tuesday.
  • Neuroderm Ltd NDRM rose 4.4 percent to $26.00 in pre-market trading. Oppenheimer upgraded NeuroDerm from Perform to Outperform
  • Sibanye Gold Ltd (ADR) SBGL rose 3.9 percent to $5.40 in pre-market trading after slipping 3.35 percent on Tuesday.
  • BioLife Solutions Inc BLFS rose 3.1 percent to $2.35 in pre-market trading after the company announced a supply agreement with Adaptimmune Therapeutics.
  • xG Technology Inc XGTI gained 3.1 percent to $2.03 after surging 8.24 percent on Tuesday.
  • Bitauto Hldg Ltd (ADR) BITA rose 3 percent to $28.08 in pre-market trading after slipping 1.98 percent on Tuesday.
  • Autohome Inc (ADR) ATHM rose 3 percent to $46.11 in pre-market trading after gaining 0.99 percent on Tuesday.


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Losers

  • Aldeyra Therapeutics Inc ALDX shares fell 18.6 percent to $4.15 in pre-market trading after the company disclosed that its Phase 2b trial did not meet primary endpoint.
  • Sequans Communications SA ADR SQNS shares fell 5.7 percent to $3.82 after the company reported a proposed offering of American Depositary Shares.
  • Hawaiian Holdings, Inc. HA shares fell 3.7 percent to $52.65 in pre-market trading. Stifel Nicolaus downgraded Hawaiian from Hold to Sell and lowered the price target from $60.00 to $40.00.
  • Whiting Petroleum Corp WLL shares fell 3.6 percent to $6.49 in the pre-market trading session after gaining 9.61 percent on Tuesday.
  • Applied Materials, Inc. AMAT fell 2.6 percent to $43.68 in pre-market trading after rising 1.15 percent on Tuesday.
  • Mondelez International Inc MDLZ shares fell 2.3 percent to $44.61 in pre-market trading after gaining 0.60 percent on Tuesday.
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