Here's a roundup of top developments in the biotech space over the last 24 hours.

Stocks In Focus

Regeneron Buys Cancer-Focused Checkmate Pharmaceuticals For $250M

Regeneron Pharmaceuticals Inc (NASDAQ:REGN) has agreed to acquire Checkmate Pharmaceuticals Inc (NASDAQ:CMPI) at $10.50 per share. 

The proposed acquisition values Checkmate's equity value at approximately $250 million.

Checkmate's lead investigational candidate is vidutolimod, an advanced generation CpG-A oligodeoxynucleotide Toll-like receptor 9 agonist delivered in a virus-like particle.

CMPI shares are surging 19.1% at $2.87 during the premarket session.

Moderna's Bivalent Booster COVID-19 Vaccine Candidate Shows Superior Neutralizing Activity Vs. SpikeVax Against Multiple Variants

Moderna Inc (NASDAQ:MRNA) has announced new clinical data from its bivalent COVID-19 booster platform.

The data includes data on the Company's first bivalent booster candidate, mRNA-1273.211, which contains mutations in several recent variants, including Omicron. 

A 50 µg booster dose of mRNA-1273.211 demonstrated superiority against Beta, Delta and Omicron variants one month after administration that continued six months after administration for Beta and Omicron variants.

A 50 µg booster dose of mRNA-1273.211 was generally well tolerated.

Shares are down 2.42% at $151.00 during the premarket session.

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AstraZeneca's Enhertu Receives Priority Review in US In Previously Treated HER2 Mutant Lung Cancer Setting

The application covers unresectable or metastatic NSCLC whose tumors have a HER2 mutation and have received prior systemic therapy. 

The application has also been granted Priority Review.

Acadia's Non-Opioid Post-Operative Pain Med Flunks In Mid-Stage Study

Acadia Pharmaceuticals Inc (NASDAQ:ACAD) announced topline results from a Phase 2 trial evaluating the efficacy and safety of ACP-044 for acute pain following bunionectomy surgery. 

A trend favoring the ACP-044 400 mg once every six hours treatment group was observed on the primary endpoint, a difference of -10.5 points compared to placebo. 

Navidea's Cancer Imaging Agent Scores Indian Approval

Tc99m tilmanocept is approved for imaging and intraoperative detection of sentinel lymph nodes draining a primary tumor in adult patients with breast cancer, melanoma, or localized squamous cell carcinoma of the oral cavity.

BioXcel Therapeutics Receives Strategic Financing Of $260M From Oaktree, Qatar Investment Authority

The Company will use the funding to support its commercial activities of Igalmi (dexmedetomidine) sublingual film and expansion of clinical development efforts of BXCL501 in agitation in patients with Alzheimer's Disease.

Full execution of this financing would result in a cash runway into 2025 for the Company.

SpringWorks Inks Trial Collaboration With Regeneron For Nirogacestat In Multiple Myeloma

Regeneron is responsible for the clinical development and will assume all costs associated with the study, other than expenses related to the manufacturing and supply of nirogacestat and certain costs related to intellectual property rights.

Amgen's Stelara-Based Biosimilar Shows Comparable Efficacy, Safety Profile For Psoriasis

The study met the primary efficacy endpoint, demonstrating no clinically meaningful differences between ABP 654 and Stelara. 

The safety profile of ABP 654 was comparable to Stelara.

ABP 654 is being developed as a biosimilar candidate to Stelara

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