U.S. indices had a mixed day of trading Wednesday as investors weigh rising COVID-19 Delta variant cases nationwide.

Here are the day's winners and losers from the Nasdaq-100, according to data from Benzinga Pro.

Moderna Inc (NASDAQ:MRNA), DexCom, Inc. (NASDAQ:DXCM) and Baidu Inc (NASDAQ:BIDU) were among the top gainers for the Nasdaq-100 Wednesday.

Autodesk, Inc. (NASDAQ:ADSK), Vertex Pharmaceuticals (NASDAQ:VRTX) and Texas Instruments (NASDAQ:TXN) were among the top losers for the Nasdaq-100.

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