Gainers

• Oculus Innovative Sciences, Inc. (NASDAQ: OCLS) rose 15.5 percent to $42.50 in pre-market trading after the company disclosed that it has sold its Latin America business to Invekra S.A.P.I. de C.V. for $19.5 million in cash.
• Angie's List Inc (NASDAQ: ANGI) shares rose 9.7 percent to $8.45 in pre-market trading. Angie's List reported a Q3 loss of $0.28 per share on revenue of $79.74 million. The company also announced plans to explore strategic alternatives.
• Silver Standard Resources Inc. (USA) (NASDAQ: SSRI) shares rose 8.3 percent to $11.87 in pre-market trading after gaining 1.95 percent on Monday.
• Oclaro, Inc. (NASDAQ: OCLR) rose 5.8 percent to $7.73 in pre-market trading after declining 0.27 percent on Monday.
• Omeros Corporation (NASDAQ: OMER) rose 4.9 percent to $8.60 in the pre-market trading after gaining 4.46 percent on Monday.
• Organovo Holdings Inc (NASDAQ: ONVO) shares rose 4.1 percent to $2.59 in pre-market trading after dropping 4.23 percent on Monday.

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Losers

• Alcoa Inc (NYSE: AA) shares fell 24.6 percent to $21.65 in pre-market trading. Alcoa has completed the separation from its parent company Alcoa Inc. and has now started operating as an independent company listed on the NYSE under the symbol “AA.”
• Canadian Natural Resource Ltd (USA) (NYSE: CNQ) shares fell 20.8 percent to $25.12 in pre-market trading after dropping 2.10 percent on Monday.
• Atara Biotherapeutics Inc (NASDAQ: ATRA) shares fell 11.3 percent to $11.35 in pre-market trading after declining 5.88 percent on Monday.
• Kamada Ltd (NASDAQ: KMDA) fell 9.4 percent to $5.30 in pre-market trading after dropping 1.68 percent on Monday.
• L Brands Inc (NYSE: LB) shares fell 7.3 percent to $66.90 in pre-market trading after the company lowered its earnings outlook for the third quarter.
• Biostar Pharmaceuticals Inc (NASDAQ: BSPM) shares fell 6.6 percent to $3.10 in pre-market trading.
• FreightCar America, Inc. (NASDAQ: RAIL) fell 6.2 percent to $12.25 in pre-market trading. Freightcar America reported Q3 net income of $51,000 on revenue of $113.5 million.
• Shire PLC (ADR) (NASDAQ: SHPG) shares fell 4.5 percent to $160.99 in the pre-market trading session. Shire reported a Q3 loss of $1.29 per share on sales of $3.452 billion and lowered its FY16 earnings outlook.
• Allot Communications Ltd (NASDAQ: ALLT) shares fell 3.7 percent to $5.00 in pre-market trading after dropping 1.33 percent on Monday.