Benzinga's Top Pre-Market Gainers

Zipcar

shares jumped 47.82% to $12.18 in pre-market trading. Avis Budget Group

announced its plans to buy Zipcar for $500 million. Synergy Pharmaceuticals

surged 15.81% to $6.08 in the pre-market session. Synergy Pharma reported positive results from Plecanatide Phase IIb/III trial in patients with Chronic Idiopathic Constipation. James River Coal Co

shares rose 9.35% to $3.51 in the pre-market trading. James River Coal shares have dropped 58.15% over the past 52 weeks, while the S&P 500 index has gained 11.68% in the same period. Neutral Tandem

gained 8.95% to $2.80 in the pre-market session. Neutral Tandem's PEG ratio is 1.35.