Plus Therapeutics Highlights Updates On Lead Program In Brain Cancer Indications - Plus Therapeutics (NASDAQ:PSTV)

Plus Therapeutics Inc PSTV presented data from two ongoing trials evaluating its lead investigational targeted radiotherapeutic, rhenium (186Re) obisbemeda, in recurrent glioblastoma (GBM), leptomeningeal metastases (LM).
Data from the first oral presentation included the following key findings:
- In 24 patients with recurrent glioblastoma, a single dose of rhenium (186Re) obisbemeda was administered in the dose escalation phase, achieving up to 740 Gray (Gy) of absorbed radiation dose to the tumor.
- No dose-limiting toxicities and a good safety profile have been observed.
- A statistically significant improvement in overall survival correlated with both the average absorbed dose of radiation to the tumor and the percent volume of tumor treated, specifically:
- A 100 Gy increase in the absorbed dose correlated with a 35.7% decrease in the risk of death.
- A 1% increase in tumor volume treated is associated with a 4.5% decrease in the risk of death.
Related: Plus Therapeutics Shares Surge On Positive Data From Lead Brain Cancer Candidate.
A recommended Phase 2 dose of 22.3 mCi in 8.8 mL is being studied for tumor volumes of 20 mL or less and is expected to enroll up to an additional 31 patients.
Data from the second oral presentation in LM patients exhibited that single rhenium (186Re) obisbemeda dose was well tolerated with no treatment-related adverse events greater than grade 1.
- All four patients treated in Cohorts 1 and 2 were observed to have prompt and complete rhenium (186Re) obisbemeda distribution throughout the cerebrospinal fluid subarachnoid space that was durable to 28 days.
- All patients showed a decreased CSF tumor cell count by microfluidic chamber assay after treatment, ranging from 46% to 92%.
Plus Therapeutics will file an Investigational New Drug application for the pediatric Phase 1/2a rhenium (186Re) obisbemeda trial in up to 24 patients with supratentorial recurrent or progressive pediatric ependymoma and high-grade glioma.
Price Action: PSTV shares closed 4.13% lower at $0.46 on Friday.

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