AstraZeneca Pulls Plug On MCL-1 Cancer Drug Trial

  • AstraZeneca Plc AZN has paused an active Phase 1 trial of AZD5991, a direct inhibitor of MCL-1, citing a potential safety issue.
  • Two years ago, the FDA hit Amgen Inc AMGN with a clinical hold on its MCL-1 inhibitor AMG 397 following signs of cardiac toxicity.
  • AstraZeneca's AZD5991 belongs to the same class therapy.
  • The trial suspension, noted on, came on October 19: "The study has been put on hold to allow further evaluation of safety-related information," the update said.
  • AstraZeneca planned to recruit 144 patients for the study, slated to complete in March 2023. 
  • The trial was assessing AZD5991, either alone or combined with AbbVie Inc ABBVRoche Holding AG's RHHBY Venetoclax in relapsed or refractory acute myeloid leukemia (AML). 
  • The drug works by targeting apoptosis, the process of programmed cell death, specifically in blood cancer.
  • Price Action: AZN shares are up 0.71% at $60.6 during the market session on the last check Wednesday.
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Posted In: BiotechNewsHealth CareGeneralacute myeloid leukemiaBriefsPhase 1 Trial
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