Bulls vs Bears
Click to unlock major analysts' bullish and bearish positions by joining Benzinga Edge.

Market sentiment signals for Spyre Therapeutics (SYRE): analyst consensus, short interest, options flow and insider activity.
Analyst Consensus
Buy
19 analysts
Options Flow (P/C)
0.00
More calls — Bullish
Avg Consensus PT
$100
+10.9%
Highest Price Target
$130
+44.6%
Lowest Price Target
$44
-51.1%
Short Interest
15.1%
Rising — Bearish
Insider Activity (30d)
Net Seller
Short Interest — % of Float
| Date | Firm | Analyst & Accuracy | Upside / Downside | PT Change | Action | Rating |
|---|---|---|---|---|---|---|
| Oct 1, 2026 | JP Morgan | Hardik Parikh— | +22.3% | $110 | Initiate | Overweight |
| Oct 1, 2026 | BTIG | Julian Harrison— | +34.5% | $121 → $121 | Maintained | Buy |