AbbVie's Migraine Treatment Scores Canadian Approval

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  • Health Canada has approved AbbVie Inc's ABBV Ubrelvy (ubrogepant) for the acute treatment of migraine, with or without aura, in adults.
  • Ubrelvy is the first orally-administered calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) for migraine attacks once they start.
  • Calcitonin gene-related peptide (CGRP) is a neuropeptide in the peripheral and central nervous systems. CGRP is released from sensory nerve endings during a migraine attack.
  • Ubrogepant blocks the binding of CGRP to its receptor and antagonizes CGRP receptor function. 
  • Related: AbbVie Reports Mixed Earnings, Tightens Guidance, Lifts Quarterly Dividend.
  • Ubrelvy was demonstrated to reduce or eliminate migraine pain with a single oral tablet, with the flexibility to take an optional second dose for persistent pain.
  • The efficacy of Ubrelvy for the acute treatment of migraine was demonstrated in two studies. These studies enrolled patients with a history of migraine with and without aura and who experienced 2 to 8 migraine attacks per month with moderate to severe headache pain. 
  • Patients were permitted to use standard migraine preventive medications during the study. At baseline, 23% percent of patients were taking preventive medications for migraine. 
  • Price Action: ABBV shares are up 2.24% at $156.47 on the last check Wednesday.
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