Lilly-Boehringer Partnered Jardiance Slows Kidney Disease Progression, Data Shows

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  • Boehringer Ingelheim and Eli Lilly And Co LLY said their diabetes drug Jardiance showed to slow the progression of chronic kidney disease.
  • The companies said the EMPA-KIDNEY phase 3 trial met its primary endpoint by demonstrating a significant kidney and cardiovascular benefit for chronic kidney disease. 
  • In March, the trial was stopped early because an independent monitoring panel found the drug's benefit to be sufficiently clear
  • When treated with Jardiance (empagliflozin), the risk of kidney disease progression or cardiovascular death was significantly reduced by 28% vs. placebo.
  • The results were announced today during the American Society of Nephrology (ASN)'s Kidney Week 2022.
  • EMPA-KIDNEY trial also demonstrated a significant reduction in all-cause hospitalizations (14%) vs. placebo, one of the pre-specified key secondary confirmatory endpoints. 
  • The overall safety data was generally consistent with previous findings, confirming the well-established safety profile of Jardiance.
  • Reductions in other key secondary endpoints of hospitalization for heart failure, cardiovascular death, or all-cause death were not statistically significant. However, the power to detect this was limited by the number of events observed.
  • Price Action: LLY shares are down 0.79% at $358.82 on the last check Friday.
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