Sanofi-GSK's Next-Gen COVID-19 Booster Shows Potential Against Variants Of Concern

  • Sanofi SA SNY said the next-gen COVID-19 vaccine candidate it has developed with GSK Plc GSK in two trials showed a potential to protect against the virus's main variants of concern when used as a booster.
  • In the Phase 3 VAT02 Cohort 2 study, the vaccine candidate showed a 15-fold increase against the parent virus and a 30-fold increase against Beta strain in adults previously primed with mRNA COVID-19 vaccines. 
  • In particular, against omicron, preliminary data show a 40-fold increase against BA.1. 
  • The Sanofi-GSK next-generation booster candidate generated double the number of neutralizing antibodies against omicron BA.1 and BA.2 compared to the original parent virus booster.
  • Related: EMA Starts Review Of Sanofi-GlaxoSmithKline's COVID-19 Vaccine.
  • An independent COVIBOOST study demonstrated that Sanofi-GSK next-generation booster generated a higher immune response after two doses of Pfizer Inc PFEBioNTech's SE BNTX COVID-19 shot than Pfizer-BioNTech's booster or the Sanofi-GSK first-generation booster.
  • In this study, which included 247 subjects, all three vaccines elicited neutralizing antibodies against the omicron BA.1 variant, with the highest responses generated by the Sanofi-GSK next-generation candidate. 
  • Across both studies, the Sanofi-GSK next-generation vaccine candidate was well-tolerated, with a favorable safety profile. 
  • In the VAT02 cohort 2 study, low numbers of Grade 3 reactions were reported, all transient and non-severe.
  • Price Action: SNY shares are down 1.16% at $50.32, and GSK stock is down 2.47% at $42.72 during the premarket session on the last check Monday.
  • Photo by hakan german from Pixabay

Posted In: BriefsCOVID-19 CoronavirusCOVID-19 VaccineBiotechLarge CapNewsHealth CareGeneral

Ad Disclosure: The rate information is obtained by Bankrate from the listed institutions. Bankrate cannot guaranty the accuracy or availability of any rates shown above. Institutions may have different rates on their own websites than those posted on The listings that appear on this page are from companies from which this website receives compensation, which may impact how, where, and in what order products appear. This table does not include all companies or all available products.

All rates are subject to change without notice and may vary depending on location. These quotes are from banks, thrifts, and credit unions, some of whom have paid for a link to their own Web site where you can find additional information. Those with a paid link are our Advertisers. Those without a paid link are listings we obtain to improve the consumer shopping experience and are not Advertisers. To receive the rate from an Advertiser, please identify yourself as a Bankrate customer. Bank and thrift deposits are insured by the Federal Deposit Insurance Corp. Credit union deposits are insured by the National Credit Union Administration.

Consumer Satisfaction: Bankrate attempts to verify the accuracy and availability of its Advertisers' terms through its quality assurance process and requires Advertisers to agree to our Terms and Conditions and to adhere to our Quality Control Program. If you believe that you have received an inaccurate quote or are otherwise not satisfied with the services provided to you by the institution you choose, please click here.

Rate collection and criteria: Click here for more information on rate collection and criteria.