Septerna Stock Short Interest Report | NASDAQ:SEPN | Benzinga

Short interest in Septerna Inc (NASDAQ:SEPN) decreased during the last reporting period, falling from 1.92M to 1.48M. This put 5.68% of the company's publicly available shares short.

Based on the recent average volume of 404.59K shares traded per day, it would take 3.65 day(s) for holders of this short interest to close out their positions without sending the stock sharply higher.

Short Interest

1.48M

Short Interest %

5.68%

Days to Cover

3.65

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SEPN	Septerna, Inc. Common Stock	11/28/2025	12/09/2025	5.68%	25,995,112	1,477,425	404,592	3.65	Get Alert
SEPN	Septerna, Inc. Common Stock	11/14/2025	11/25/2025	7.39%	25,995,112	1,921,591	352,486	5.45	Get Alert
SEPN	Septerna, Inc. Common Stock	10/31/2025	11/11/2025	7.79%	25,995,112	2,025,667	262,507	7.72	Get Alert
SEPN	Septerna, Inc. Common Stock	10/15/2025	10/24/2025	9.96%	25,806,055	2,571,016	442,902	5.8	Get Alert
SEPN	Septerna, Inc. Common Stock	09/30/2025	10/09/2025	11.91%	25,806,055	3,074,377	267,550	11.49	Get Alert
SEPN	Septerna, Inc. Common Stock	09/15/2025	09/24/2025	12.28%	25,806,055	3,168,890	257,318	12.32	Get Alert
SEPN	Septerna, Inc. Common Stock	08/29/2025	09/10/2025	11.94%	25,806,055	3,082,422	212,903	14.48	Get Alert
SEPN	Septerna, Inc. Common Stock	08/15/2025	08/26/2025	12.25%	25,806,055	3,162,368	243,303	13	Get Alert
SEPN	Septerna, Inc. Common Stock	07/31/2025	08/11/2025	12.31%	25,779,258	3,174,316	213,175	14.89	Get Alert
SEPN	Septerna, Inc. Common Stock	07/15/2025	07/24/2025	14.51%	25,779,258	3,740,655	305,478	12.25	Get Alert
SEPN	Septerna, Inc. Common Stock	06/30/2025	07/10/2025	13.90%	25,779,258	3,584,250	566,831	6.32	Get Alert
SEPN	Septerna, Inc. Common Stock	06/13/2025	06/25/2025	14.61%	25,779,258	3,766,755	523,856	7.19	Get Alert
SEPN	Septerna, Inc. Common Stock	05/30/2025	06/10/2025	17.04%	25,779,258	4,391,879	850,547	5.16	Get Alert
SEPN	Septerna, Inc. Common Stock	05/15/2025	05/27/2025	17.70%	25,779,258	4,564,114	3,858,767	1.18	Get Alert
SEPN	Septerna, Inc. Common Stock	04/30/2025	05/09/2025	12.40%	25,736,623	3,191,104	189,585	16.83	Get Alert
SEPN	Septerna, Inc. Common Stock	04/15/2025	04/25/2025	—	—	3,344,710	264,472	12.65	Get Alert
SEPN	Septerna, Inc. Common Stock	03/31/2025	04/09/2025	—	—	3,173,173	271,842	11.67	Get Alert
SEPN	Septerna, Inc. Common Stock	03/14/2025	03/25/2025	—	—	2,976,192	567,914	5.24	Get Alert
SEPN	Septerna, Inc. Common Stock	02/28/2025	03/11/2025	—	—	2,676,344	1,668,164	1.6	Get Alert
SEPN	Septerna, Inc. Common Stock	02/14/2025	02/26/2025	—	—	3,079,226	286,829	10.74	Get Alert
SEPN	Septerna, Inc. Common Stock	01/31/2025	02/11/2025	—	—	2,236,366	211,243	10.59	Get Alert
SEPN	Septerna, Inc. Common Stock	01/15/2025	01/27/2025	—	—	2,406,260	207,420	11.6	Get Alert
SEPN	Septerna, Inc. Common Stock	12/31/2024	01/10/2025	—	—	2,451,040	653,269	3.75	Get Alert
SEPN	Septerna, Inc. Common Stock	12/13/2024	12/24/2024	—	—	1,009,713	265,174	3.81	Get Alert
SEPN	Septerna, Inc. Common Stock	11/29/2024	12/10/2024	—	—	756,477	150,614	5.02	Get Alert
SEPN	Septerna, Inc. Common Stock	11/15/2024	11/26/2024	—	—	545,717	165,676	3.29	Get Alert
SEPN	Septerna, Inc. Common Stock	10/31/2024	11/11/2024	—	—	437,539	368,343	1.19	Get Alert