Septerna (SEPN) Stock Price Target 2026

The average analyst price target for Septerna is $51.50, 1.0% below the current price. Of 10 analysts, 10 rate it Buy. Targets range from $25 to $65. The latest change came on Nov 10, 2026, when Stifel raised its price target on Septerna from $49 to $60 and kept a Buy rating.

The Average Analyst Price Target for Septerna is $51.50.

Price Target Range — 9 Quarters

Analyst Consensus — 10 Analysts

1S.Buy

9Buy

Consensus RatingBuy# Analysts10Avg. Consensus PT$51.50Upside to Avg. PT-1.0%

Rating Trend — Last 9 Months

Latest Upgrades and Downgrades for Septerna Stock

See all ratings →

Date	Firm	Analyst	Action	Rating Change	Price Target
Nov 10, 2026	Stifel	Alex Thompson	PT Raise	Buy	$49→$60
Nov 6, 2026	Guggenheim	Seamus Fernandez	PT Raise	Buy	$51→$65
Nov 4, 2026	Wells Fargo	Derek Archila	PT Raise	Overweight	$50→$61
Aug 19, 2026	JP Morgan	Tessa Romero	PT Raise	Overweight	$38→$48
Aug 13, 2026	Jones Trading	Catherine Novack	PT Raise	Buy	$43→$62
Aug 12, 2026	Wells Fargo	Derek Archila	PT Raise	Overweight	$48→$50
Aug 12, 2026	HC Wainwright & Co.	Raghuram Selvaraju	PT Raise	Buy	$40→$60
Aug 11, 2026	Guggenheim	Seamus Fernandez	PT Raise	Buy	$45→$51
Jul 1, 2026	Guggenheim	Seamus Fernandez	PT Cut	Buy	$52→$45
Jul 1, 2026	HC Wainwright & Co.	Raghuram Selvaraju	Maintained	Buy	$40
Jul 1, 2026	Truist Securities	Srikripa Devarakonda	PT Raise	Buy	$35→$43
Jun 8, 2026	Raymond James	Martin Auster	PT Raise	Strong Buy	$47→$53
May 13, 2026	HC Wainwright & Co.	Raghuram Selvaraju	Maintained	Buy	$40
Apr 14, 2026	HC Wainwright & Co.	Raghuram Selvaraju	Maintained	Buy	$40
Mar 24, 2026	JP Morgan	Tessa Romero	PT Raise	Overweight	$34→$38
Mar 11, 2026	Truist Securities	Srikripa Devarakonda	PT Raise	Buy	$34→$35
Mar 3, 2026	Wells Fargo	Derek Archila	PT Raise	Overweight	$28→$48
Mar 2, 2026	HC Wainwright & Co.	Raghuram Selvaraju	PT Raise	Buy	$35→$40
Jan 20, 2026	HC Wainwright & Co.	Raghuram Selvaraju	PT Raise	Buy	$30→$35
Dec 23, 2025	Jones Trading	Catherine Novack	Initiate	Buy	$43