| Sep 15, 2026 | PABLO CAGNONI | PRESIDENT, GLOBAL HEAD R&D | SELL-OPTIONS | — | $93.44 | $1.3M |
| Aug 19, 2026 | PABLO CAGNONI | PRESIDENT, GLOBAL HEAD R&D | SELL | 10.801K | $125.56 | $1.4M |
| Aug 12, 2026 | PABLO CAGNONI | PRESIDENT, GLOBAL HEAD R&D | SELL | 10.803K | $120.04 | $1.3M |
| Aug 5, 2026 | PABLO CAGNONI | PRESIDENT, GLOBAL HEAD R&D | SELL | 10.640K | $122.69 | $1.3M |
| Aug 5, 2026 | Patrick Mayes | EVP & CHIEF SCIENTIFIC OFFICER | SELL-OPTIONS | — | $115.23 | $39K |
| Jul 31, 2026 | PABLO CAGNONI | PRESIDENT, GLOBAL HEAD R&D | SELL | 15.888K | $119.70 | $1.9M |
| Jul 31, 2026 | Patrick Mayes | EVP & CHIEF SCIENTIFIC OFFICER | SELL | 2.187K | $99.03 | $2.1M |
| Jul 16, 2026 | Steven Stein | CMO & HEAD LATE-STAGE DEV. | GRANT | 7.921K | $114.73 | $215K |
| Jul 16, 2026 | Khairie Mohamed Issa | EVP, HEAD U.S. COMMERCIAL | GRANT | 6.764K | $115.01 | $126K |
| Jul 14, 2026 | Steven Stein | CMO & HEAD LATE-STAGE DEV. | SELL | 53.155K | $113.92 | $6.1M |
| Jun 4, 2026 | Thomas Tray | PRINCIPAL ACCOUNTING OFFICER | SELL-OPTIONS | — | $91.91 | $43K |
| May 26, 2026 | Thomas Tray | PRINCIPAL ACCOUNTING OFFICER | SELL | 2.051K | $97.35 | $200K |
| May 19, 2026 | Paul Clancy | DIRECTOR | SELL-OPTIONS | — | $89.73 | $156K |
| Apr 17, 2026 | PABLO CAGNONI | PRESIDENT, GLOBAL HEAD R&D | SELL-OPTIONS | — | $82.96 | $505K |
