AbbVie's Preventive Treatment For Migraine Meets Primary Goal In Patients With Failed Medications - AbbVie (NYSE:ABBV)

AbbVie Inc ABBV announced data from its Phase 3 ELEVATE study, evaluating atogepant for the preventive treatment of episodic migraine in people who had previously failed two to four classes of oral preventive medications.
The ELEVATE study met all primary and secondary endpoints. It demonstrated a statistically significant reduction in monthly migraine days (MMDs) for those with episodic migraine taking atogepant 60 mg QD compared to placebo.
The primary endpoint was the change from baseline in mean MMDs across 12 weeks. The secondary endpoints included achievement of more than 50% reduction in MMDs, change from baseline in MMDs, and change from baseline in acute medication use days across 12 weeks.
The study results demonstrated that patients in the atogepant 60 mg once daily (QD) arm experienced a decrease of 4.20 days in their MMDs across the 12-week treatment period, greater than the 1.85-day reduction observed in the placebo arm.
Atogepant 60 mg QD was well tolerated.
The most commonly reported treatment-emergent adverse events (atogepant vs. placebo, respectively) included constipation (10.3% vs. 2.5%), COVID-19 (8.3% vs. 9.6%), nausea (7.1% vs. 3.2%), and nasopharyngitis (5.1% vs. 7.6%).
The FDA recently approved Qulipta as the first and only oral calcitonin gene-related peptide receptor antagonist proven to prevent both episodic and chronic migraine in adults in the U.S.
Price Action: ABBV shares are down 0.33% at $161.21 during the premarket session on the last check Friday.

Market News and Data brought to you by Benzinga APIs