Daiichi, Zymeworks Terminate Seven Year-Cancer Antibody Pact

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  • Zymeworks Inc ZYME and Daiichi Sankyo DSNKY terminated a license agreement dated September 26, 2016, as amended on September 25, 2018, July 2, 2021, and June 6, 2022.
  • Under the 2016 agreement, Zymeworks licensed its Azymetric and EFECT platforms to Daiichi Sankyo to develop one bispecific antibody therapy for an upfront technology access fee payment of $2.0 million and research and commercial option-related payments totaling $4.5 million. 
  • Zymeworks was also eligible to receive additional development milestone payments of up to $63.4 million and commercial milestone payments of up to $80.0 million.
  • Also See: Jazz Pharma, Zymeworks Highlight 84% Overall Survival At 18 Months From Zanidatamab In Esophageal Cancer.
  • Zymeworks also gained non-exclusive rights to develop and commercialize up to three products (revised to up to six under the June 2022 amendment) using Daiichi Sankyo's proprietary immune-oncology antibodies. 
  • Under the non-exclusive immune-oncology antibody license, Zymeworks was solely responsible for the resulting products' research, development, and commercialization.
  • Zymeworks reported $492.2 million in cash resources as of December 31, 2022, with an expected cash runway through 2026.
  • Price Action: ZYME shares are down 0.54% at $8.32 on the last check Monday.
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