SELLAS Life Sciences' GPS Combo Therapy Shows Overall Survival Of 18 Months In Pretreated Ovarian Cancer Patients

  • SELLAS Life Sciences Group Inc SLS announced confirmatory topline data from the final analysis of results from its Phase 1/2 trial of galinpepimut-S (GPS).
  • The trial assessed GPS in combination with Merck & Co Inc's MRK Keytruda (pembrolizumab) for WT1(+) relapsed or refractory platinum-resistant advanced metastatic ovarian cancer.
  • Median Overall Survival (OS) was 18.4 months compared to 13.8 months in a checkpoint inhibitor single-agent study.
  • Also Read: SELLAS Life Sciences Touts Encouraging Preclinical Data For Candidate For Aggressive Form Of Prostate Cancer.
  • Median Progression-Free Survival (PFS) was 12 weeks compared to eight weeks.
  • The trial's overall response rate (ORR) is 6.3%, with a disease control rate (DCR. 
  • In a checkpoint inhibitor single-agent study in a similar platinum-resistant ovarian cancer patient population treated with a checkpoint inhibitor alone, the observed DCR was 37.2%.
  • The safety profile of GPS in combination with pembrolizumab was similar to pembrolizumab alone, with the only addition of low-grade, rapidly resolving local reactions at the GPS injection site.
  • In May, the company announced data from a clinical trial of GPS plus Bristol-Myers Squibb Co's BMY Opdivo (nivolumab), showing a median overall survival (OS) of 40.9 weeks (9.4 months).
  • Price Action: SLS shares are down 5.34% at $4.68 on the last check Thursday.
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