Arcturus' COVID-19 Booster Shows Durability Against Omicron Variants

Arcturus' COVID-19 Booster Shows Durability Against Omicron Variants
  • Arcturus Therapeutics Holdings Inc ARCT announced updated data from its ongoing ARCT-154 booster clinical trial. 
  • The new results demonstrate a broad neutralizing antibody response against omicron variants of concern, including BA.5, lasting up to at least six months after administering a low-dose (5 mcg) ARCT-154 booster.
  • “Our next generation low-dose self-amplifying (STARR™) mRNA technology continues to differentiate itself from conventional mRNA vaccine technology,” said Joseph Payne, President & CEO.
  • “Further validation of the breadth and duration for the immune responses to ARCT-154 are planned in upcoming pivotal clinical trial activities,” he added.
  • Related: Arcturus Reports Three-Month Durability Results From ARCT-154 COVID-19 Booster Trial.
  • After one month and three months, neutralizing antibody responses to Omicron BA.5 were 33- and 20-fold elevated over pre-boost responses, respectively. 
  • After six months, neutralizing antibody responses to omicron BA.1, BA.2, and BA.5 ranged from 22-52 fold, 25-55 fold and 9-24 fold elevated over pre-boost responses, respectively.
  • These data show sustained neutralizing responses to antigenically distinct variants of concern, including omicron BA.5, for at least six months after vaccination.
  • Price Action: ARCT shares are down 6.79% at $19.05 on the last check Thursday.

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