Omega Therapeutics Touts Encouraging Preclinical Data In Liver Cancer Animal Models

  • Omega Therapeutics Inc OMGA has presented new preclinical data on its lead product candidate, OTX-2002, in multiple models of hepatocellular carcinoma.
  • In non-human primates, treatment with OTX-2002 resulted in a durable reduction of MYC mRNA levels in the liver consistent with previous in vitro and in vivo studies.
  • OTX-2002 treatment decreased c-Myc mRNA, protein levels, and cell viability in multiple HCC cell lines while sparing normal cells.
  • Related: Omega Therapeutics Submits IND For Liver Cancer Candidate.
  • OTX-2002 significantly reduced tumor growth in HCC xenografts models.
  • OTX-2002 treatment is associated with decreased expression of the immune checkpoint factor PD-L1 in HCC cells, suggesting a potential role for combination therapy with immune checkpoint inhibitors.
  • Combining OTX-2002 with the existing standard of care therapies for HCC resulted in further reduction of cell viability and tumor burden in both in vitro and in vivo HCC models.
  • Price Action: OMGA shares are down 1.41% at $4.20 during the market session on the last check Thursday.
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