Scynexis's Oral Ibrexafungerp Shows Potency Against Severe Fungal Infections

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  • SCYNEXIS Inc SCYX has announced interim data from its ongoing Phase 3 FURI and CARES studies of ibrexafungerp in severe fungal infections.
  • FURI study included fungal infections patients who are either intolerant to standard antifungal therapy or experience refractory fungal infections despite treatment. 
  • The CARES study is evaluating oral ibrexafungerp in patients with systemic infections caused by C. auris.
  • Related: Scynexis Aces Ibrexafungerp Late-Stage Study To Prevent Vaginal Yeast Infections.
  • Of the 131 study cases analyzed, 61.1% achieved a complete or partial response or clinical improvement.
  • 22.1% achieved stable disease, a favorable outcome in patients with severe progressive fungal infections.
  • 11.5% were considered no response, including two patients who died of an underlying condition unrelated to the treatment, and 5.3% were indeterminate.
  • SCYNEXIS will present additional details from these interim analyses at the 32nd European Congress of Clinical Microbiology and Infectious Diseases.
  • SCYNEXIS has priced its underwritten public offering of common stock, pre-funded warrants, and warrants for gross proceeds of $45 million.
  • The shares and warrants have an offer price of $3.00, and the pre-funded warrants are being sold at $2.999. 
  • Price Action: SCYX shares are down 23.30% at $2.41 during the market session on the last check Friday.
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