Atea Pharma's AT-527 Rapidly Reduces Viral Load Levels In Hospitalized COVID-19 Patients - Atea Pharmaceuticals (NASDAQ:AVIR), Roche Holding (OTC:RHHBF), Roche Holding (OTC:RHHVF), Roche Holding (OTC:RHHBY)

Atea Pharmaceuticals Inc AVIR has announced positive interim results from a Phase 2 study evaluating AT-527 in hospitalized patients with mild-to-moderate COVID-19.
Roche Holding AG RHHBY and Atea jointly develop AT-527, an oral direct-acting antiviral agent derived from Atea's purine nucleotide prodrug platform.
On Day 2, patients receiving AT-527 experienced a 0.7 log10 (80%) greater mean reduction from baseline viral load than placebo.
AT-527's antiviral activity was also observed in patients with higher baseline viral loads.
The AT-527 arm achieved SARS-CoV-2 clearance as early as Day 2 (in 6% of patients), Day 8 (in 7% of patients), Day 10 (in 33% of patients), and Day 12 (in 31% of patients) compared to 0% of patients in the placebo arm.
By Day 14 (last viral sampling study day), approximately 47% of patients in the AT-527 arm and 22% in the placebo arm had no detectable RNA virus.
No drug-related serious adverse events were reported, and AT-527 was safe and well-tolerated.
Final data from the complete Phase 2 program will be submitted to an upcoming medical congress or a peer-reviewed publication.
Price Action: AVIR shares are down 7.87% at $22.49 during the market session on the last check Wednesday.