I-Mab Showcases Early Data On Uliledlimab/Atezolizumab Combo In Advanced Cancer Settings

  • I-Mab IMAB unveiled early results from Phase 1 study evaluating uliledlimab in combination with Roche Holdings AG’s RHHBY Tecentriq (atezolizumab) in patients with advanced cancer.
  • An abstract detailing data from the trial will be presented at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place next month.
  • I-Mab touted a 23% objective response rate and disease control rate of 46% in the study among 13 evaluable patients with several different types of advanced cancers.
  • A patient with ovarian cancer achieved a complete response; two others saw a partial response, while three had stable disease.
  • In particular, investigators reported no “hook effect” in the Phase I trial, meaning the antibody potency seemed to increase proportionately with the dose rather than losing inhibition at a higher dose, an issue observed with certain other drugs in the class.
  • The clinical activity was observed in both PD-(L)1 treatment naïve and refractory cancer patients, including one partial response patient who previously failed Bristol-Myers Squibb Co’s BMY Opdivo (nivolumab).
  • The combination was safe and well-tolerated with no dose-limiting toxicity. All treatment-related adverse events were either mild or moderate.
  • Price Action: IMAB shares closed at $63.46 on Wednesday.
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