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Inhibrx Inc (NASDAQ: INBX) has announced results from the dose escalation of the Phase 1 study evaluating INBRX-105 in locally advanced or metastatic solid tumors.
- INBRX-105 is a precisely engineered multi-specific therapeutic candidate based on a single-domain antibody platform.
- It is designed to agonize 4-1BB selectively in the presence of programmed death-ligand 1, a protein that is typically found in the tumor microenvironment and lymphoid tissues.
- The 32-subject trial was designed to determine the safety profile and identify the maximum tolerated dose and/or recommended Phase 2 dose of INBRX-105 administered as a single agent or in combination with Merck & Co's (NYSE: MRK) Keytruda (pembrolizumab).
- Dose-limiting toxicities were observed at several dose levels and determined the 1 mg/kg dose level as the maximum tolerated dose of INBRX-105.
- Eight out of 18 evaluable patients (44%) receiving INBRX-105 achieved stable disease, with the greatest reduction in tumor volume observed to be 20%.
- The longest duration of the treatment with INBRX-105 was 41 weeks or approximately nine and a half months.
- The Dose-escalation cohort of INBRX-105, in combination with Keytruda, will start enrollment during the second quarter of 2021.
- Initial data is expected during the fourth quarter of 2021.
- Additionally, the company reported cash and cash equivalents of $128.7 million as of 31 December 2020.
- Price Action: INBX shares are down 4% at $24.1 in market trading hours on the last check Friday.
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