Skip to main content

Market Overview

Aerpio Pharmaceuticals' Razuprotafib Dropped From Collaborative COVID-19 Trial

Share:
  • Quantum Leap Healthcare Collaborative-sponsored I-SPY COVID Trial will not further test Aerpio Pharmaceuticals Inc's (NASDAQ: ARPO) razuprotafib.
  • Razuprotafib was chosen because it was believed to stabilize and repair the lung's blood vessels and improve gas exchange.
  • The I-SPY COVID Phase 2 Trial is an adaptive platform that is testing agents that promise to reduce the risk of death from and severity of illness after contracting COVID-19.
  • Aerpio's razuprotafib will not be evaluated because it was challenging to administer in the setting of COVID-19, with 30% of patients discontinuing the agent due to disease-related hypotension (low blood pressure).
  • A small decline in systolic blood pressure and mean arterial blood pressure by approximately 4–5 mm Hg was observed after two safety lead-in cohorts.
  • There was no indication that razuprotafib caused the hypotension that led to a clinical decline in systolic blood pressure.
  • There was no significant difference between the 10 mg and 20 mg doses in blood pressure decline was seen.
  • Blood pressure monitoring with additional scrutiny is challenging in the setting of a surge in ICU admissions from COVID-19. Hence, the Data Monitoring Committee recommended that razuprotafib not be advanced after the second safety lead-in.
  • Price Action: ARPO shares are down 5.8% at $1.46 in premarket trading on the last check Friday.
 

Related Articles (ARPO)

View Comments and Join the Discussion!

Posted-In: Covid-19Biotech News Health Care FDA General

Don't Miss Any Updates!
News Directly in Your Inbox
Subscribe to:
Benzinga Premarket Activity
Get pre-market outlook, mid-day update and after-market roundup emails in your inbox.
Market in 5 Minutes
Everything you need to know about the market - quick & easy.
Fintech Focus
A daily collection of all things fintech, interesting developments and market updates.
SPAC
Everything you need to know about the latest SPAC news.
Thank You

Thank you for subscribing! If you have any questions feel free to call us at 1-877-440-ZING or email us at vipaccounts@benzinga.com