Ayala Pharmaceuticals Raises $25M Via Equity To Fund AL102 Development In Connective Tissue Tumors

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  • Ayala Pharmaceuticals Inc (NASDAQ: AYLAwill raise $25 million via a private placement of around 1.7 million units at $15 per unit from institutional investors, including Redmile Group and SIO Capital Management. Each unit consists of one Ayala share and a warrant to purchase 0.35 shares at an exercise price of $18.10.
  • The placement is expected to close by February 23, and Ayala notes that the additional funding will extend its cash runway into 2023.
  • The funds will support the development of AL102 into a pivotal Phase 2/3 study for desmoid tumors (aggressive fibromatosis or desmoid-type fibromatosis). It is a rare connective tissue tumor typically in the upper and lower extremities, abdominal wall, head and neck area, mesenteric root, and chest wall.
  • The Phase 2/3 RINGSIDE study in adult and adolescent patients with desmoid tumors will start in the first half of 2021, with an initial interim data read-out from part 1 and dose selection expected by mid-2022.
  • AL102 is an oral gamma-secretase inhibitor currently being developed for desmoid tumors and in combination with Novartis' B-cell maturation antigen (BCMA)-targeting agents for the treatment of multiple myeloma.
  • Jefferies LLC is acting as the exclusive placement agent for the private placement.
  • Price Action: AYLA gained 5.03% at $19.01 in market trading hours on last check Friday.
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Posted In: BiotechNewsOfferingsFDAGeneralConnective Tissue TumorsPhase 2 Clinical Trial
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