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Exelixis' Cabozantinib Data Shows Clinically Significant Benefit Versus Pfizer's Sutent, In A Type Of Kidney Cancer

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  • Exelixis Inc (NASDAQ: EXEL) has reported new data from the Phase 2 (PAPMET) study evaluating CABOMETYX (cabozantinib) compared with Pfizer Inc's (NYSE: PFE) Sutent (sunitinib) in patients with metastatic papillary renal cell carcinoma (PRCC), a form of kidney cancer.
  • Exelixis presented the data at the American Society of Clinical Oncology's Genitourinary Cancers Symposium. It will publish the findings simultaneously in the Lancet.
  • CABOMETYX demonstrated Median progression-free survival of 9.0 months (n=44) versus 5.6 months with sunitinib (n=46), trial's primary endpoint. The overall response rate was 23% for CABOMETYX versus 4% for sunitinib. Median overall survival was 20 months for cabozantinib and 16.4 months for sunitinib, which did not reach statistical significance.
  • Enrollment into additional arms of the study examining the use of crizotinib or savolitinib compared to sunitinib was halted early based on predefined interim futility analyses.
  • On the safety front, the most common severe/life-threatening adverse events with CABOMETYX were hypertension (32%), hand-foot syndrome (20%), and fatigue (13%). One death, secondary to a thromboembolic event, was reported for a patient receiving CABOMETYX.
  • The discontinuation rate of study medications due to treatment-related adverse events was 24% for sunitinib and 23% for CABOMETYX.
  • Last week, the Company reported Cabometyx combined with Bristol Myers Squibb's Opdivo doubled median progression-free survival (17.0 months vs. 8.3 months) compared to sunitinib, the trial's primary endpoint, in the first-line treatment of advanced renal cell carcinoma.
  • Price Action: EXEL gained 2.24% at $22.4 in premarket trading on the last check Tuesday.
 

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Posted-In: Kidney Cancer Phase 2Biotech News Health Care General

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