| Oct 1, 2026 | Lawrence Klein | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $45.71 | $1.9M |
| Sep 21, 2026 | Arjun Agarwal | SENIOR VICE PRESIDENT, FINANCE | SELL | 533.000 | $95.75 | $51K |
| Sep 21, 2026 | Paul Quinlan | GENERAL COUNSEL | SELL-OPTIONS | — | $50.72 | $858K |
| Sep 15, 2026 | Joana Goncalves | CHIEF MEDICAL OFFICER | SELL | 947.000 | $49.85 | $683K |
| Sep 15, 2026 | Lawrence Klein | CHIEF EXECUTIVE OFFICER | SELL | 2.452K | $95.71 | $235K |
| Sep 15, 2026 | Paul Quinlan | GENERAL COUNSEL | SELL | 1.039K | $95.71 | $99K |
| Sep 15, 2026 | Laura Sandler | CHIEF OPERATING OFFICER | SELL | 906.000 | $95.71 | $87K |
| Sep 11, 2026 | Arjun Agarwal | SENIOR VICE PRESIDENT, FINANCE | SELL | 560.000 | $54.15 | $776K |
| Sep 1, 2026 | Laura Sandler | CHIEF OPERATING OFFICER | SELL-OPTIONS | — | $49.81 | $420K |
| Sep 1, 2026 | Lawrence Klein | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $49.82 | $6.3M |
| Aug 17, 2026 | Joana Goncalves | CHIEF MEDICAL OFFICER | SELL-OPTIONS | — | $59.58 | $732K |
| Aug 14, 2026 | Paul Quinlan | GENERAL COUNSEL | SELL-OPTIONS | — | $60.04 | $5.0M |
| Aug 13, 2026 | Arjun Agarwal | SENIOR VICE PRESIDENT, FINANCE | SELL-OPTIONS | — | $61.17 | $910K |
| Jul 15, 2026 | Joana Goncalves | CHIEF MEDICAL OFFICER | SELL-OPTIONS | — | $46.80 | $553K |
| Jul 13, 2026 | Arjun Agarwal | SENIOR VICE PRESIDENT, FINANCE | SELL-OPTIONS | — | $50.16 | $689K |
| Jul 1, 2026 | Fairmount Funds Management LLC, Fairmount Healthcare Fund II LP, Fairmount Healthcare CoInvest III LP, Tomas Kiselak, Evan Peter Harwin | DIRECTOR | SELL-OPTIONS | — | $84.43 | $300.0M |
| Jul 1, 2026 | Laura Sandler | CHIEF OPERATING OFFICER | SELL-OPTIONS | — | $51.11 | $433K |
| Jun 22, 2026 | Arjun Agarwal | SENIOR VICE PRESIDENT, FINANCE | SELL | 1.587K | $80.95 | $128K |
| Jun 15, 2026 | Joana Goncalves | CHIEF MEDICAL OFFICER | SELL | 947.000 | $38.30 | $499K |
| Jun 15, 2026 | Lawrence Klein | CHIEF EXECUTIVE OFFICER | SELL | 1.729K | $69.69 | $120K |
| Jun 15, 2026 | Laura Sandler | CHIEF OPERATING OFFICER | SELL | 600.000 | $69.69 | $42K |
| Jun 15, 2026 | Paul Quinlan | GENERAL COUNSEL | SELL | 733.000 | $69.69 | $51K |
| Jun 12, 2026 | Arjun Agarwal | SENIOR VICE PRESIDENT, FINANCE | SELL | 395.000 | $42.80 | $537K |
| Jun 11, 2026 | Carl Dambkowski | DIRECTOR | SELL | 35.000K | $70.13 | $2.5M |
| May 21, 2026 | Carl Dambkowski | DIRECTOR | SELL | 42.740K | $33.46 | $5.7M |
| May 18, 2026 | Arjun Agarwal | SENIOR VICE PRESIDENT, FINANCE | SELL | 2.457K | $43.93 | $382K |
| May 15, 2026 | Joana Goncalves | CHIEF MEDICAL OFFICER | SELL-OPTIONS | — | $34.58 | $382K |
| May 1, 2026 | Laura Sandler | CHIEF OPERATING OFFICER | SELL-OPTIONS | — | $35.84 | $280K |
| Apr 15, 2026 | Joana Goncalves | CHIEF MEDICAL OFFICER | SELL-OPTIONS | — | $36.72 | $412K |
