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Navidea Biopharmaceuticals Data to be Presented at Society of Nuclear Medicine and Molecular Imaging Annual Meeting

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Navidea Biopharmaceuticals, Inc. (NYSE:NAVB) ("Navidea" or the
"Company"), a company focused on the development of precision
immunodiagnostic agents and immunotherapeutics, today announced that
Arash Kardan, M.D., will give an oral presentation on the results of the
Company's NAV3-21 clinical study at the Society of Nuclear Medicine and
Molecular Imaging ("SNMMI") Annual Meeting in June 2019. The
presentation is titled "A Phase I/Phase II Study of Intravenously ("IV")
Administered Tc99m Tilmanocept ("TCT") to Determine Safety,
Tolerability, Optimal Clinical Dose Selection, and Imaging Timepoint in
Patients Clinically Diagnosed with Rheumatoid Arthritis ("RA")." In
addition, an abstract of the presentation will be published in the Journal
of Nuclear Medicine
.

The NAV3-21 study enrolled subjects with active, moderate-to-severe RA
and healthy controls. Images were acquired one hour and three hours
post-injection of Tc99m tilmanocept. Results from the completed trial
demonstrate that Tc99m tilmanocept is well-tolerated with no serious
adverse events, adverse drug reactions, or drug-related adverse events
observed. Additionally, static planar images revealed joint-specific
Tc99m tilmanocept localization in RA subjects to disease-involved joints
of the shoulders, knees, hands, and feet, but no joint-specific
localization in healthy control subjects, revealing potentially
significant immunodiagnostic information about CD206-expressing synovial
macrophage involvement in RA. Enhanced anatomic delineation in
tilmanocept-positive joints of RA patients was noted via IV
administration in this trial when compared to subcutaneous
administration of Tc99m tilmanocept studied in a previously-completed
Phase 1 trial.

Michael Rosol, Chief Medical Officer for Navidea, said, "Using
noninvasive planar imaging and SPECT/CT with Tc99m tilmanocept we can,
for the first time, objectively visualize and directly quantify RA
disease activity and evaluate joint-specific inflammation. This could
also enable noninvasive characterization of joint-level pathobiology and
individualization of treatment." Dr. Rosol continued, "The results from
this and our previously completed RA trial support our initiative for
follow-on Phase 2b and Phase 3 studies intended to garner FDA approval
of new indications for Tc99m tilmanocept in RA patients."

RA is a chronic disease affecting over 1.3 million Americans and as much
as 1% of the worldwide population.1 If the product is
successfully developed, Navidea would expect to play a major role in the
management of RA patients worldwide.

Additional information can be found at http://www.snmmi.org/AM/

Reference

1. https://www.rheumatoidarthritis.org/ra/facts-and-statistics/

About Navidea

Navidea Biopharmaceuticals, Inc. (NYSE:NAVB) is a
biopharmaceutical company focused on the development of precision
immunodiagnostic agents and immunotherapeutics. Navidea is developing
multiple precision-targeted products based on its Manocept™ platform to
enhance patient care by identifying the sites and pathways of disease
and enable better diagnostic accuracy, clinical decision-making, and
targeted treatment. Navidea's Manocept platform is predicated on the
ability to specifically target the CD206 mannose receptor expressed on
activated macrophages. The Manocept platform serves as the molecular
backbone of Tc99m tilmanocept, the first product developed and
commercialized by Navidea based on the platform. The development
activities of the Manocept immunotherapeutic platform are being
conducted by Navidea in conjunction with its subsidiary, Macrophage
Therapeutics, Inc. Navidea's strategy is to deliver superior growth and
shareholder return by bringing to market novel products and advancing
the Company's pipeline through global partnering and commercialization
efforts.

For more information, please visit www.navidea.com.

Forward-Looking Statements

This release and any oral statements made with respect to the
information contained in this release contains forward-looking
statements within the meaning of Section 27A of the Securities Act of
1933, as amended, and Section 21E of the Securities Exchange Act of
1934, as amended. We have based these forward-looking statements largely
on our current expectations and projections about future events and
financial trends affecting the financial condition of our business.
These forward-looking statements are subject to a number of risks,
uncertainties and assumptions, including, among other things: any future
actions by Platinum-Montaur; general economic and business conditions,
both nationally and in our markets; our history of losses and
uncertainty of future profitability; the final outcome of any pending
litigation; our ability to successfully complete research and further
development of our drug candidates; the timing, cost and uncertainty of
obtaining regulatory approvals of our drug candidates; our ability to
successfully commercialize our drug candidates; our expectations and
estimates concerning future financial performance, financing plans and
the impact of competition; our ability to raise capital sufficient to
fund our development and commercialization programs; our ability to
implement our growth strategy; anticipated trends in our business;
advances in technologies; our ability to comply with the NYSE American
continued listing standards; our ability to maintain effective internal
control over financial reporting; and other risk factors detailed in our
most recent Annual Report on Form 10-K and other SEC filings. You are
urged to carefully review and consider the disclosures found in our SEC
filings, which are available at www.sec.gov or
at http://ir.navidea.com.

Investors are urged to consider statements that include the words
"will," "may," "could," "should," "plan," "continue," "designed,"
"goal," "forecast," "future," "believe," "intend," "expect,"
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the negatives of those words or other comparable words, to be uncertain
forward-looking statements.

You are cautioned not to place undue reliance on any forward-looking
statements, any of which could turn out to be incorrect. We undertake no
obligation to update publicly or revise any forward-looking statements,
whether as a result of new information, future events or otherwise after
the date of this report. In light of these risks and uncertainties, the
forward-looking events and circumstances discussed in this report may
not occur and actual results could differ materially from those
anticipated or implied in the forward-looking statements.

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