BioTime to Present Data at the Military Health System Research Symposium

BioTime, Inc. BTX, a clinical-stage biotechnology company focused on degenerative diseases, today announced that it will be presenting a poster at the Military Health System Research Symposium (MHSRS) from August 20-23, 2018 in Kissimmee, Florida.

The poster presentation is titled, "Next generation disease modifying viscosupplementation to delay or prevent invasive surgery in combat-related Post Traumatic Osteoarthritis (PTOA)." Dr. Thomas Zarembinski, PhD, MBA and Head of External R&D for BioTime will present the data on Tuesday, August 21^st during the Extremity and Craniomaxillofacial Regeneration session.

The poster describes the ability of a novel DNA-based small molecule to decrease cartilage degradation and turnover normally associated with osteoarthritis as well as the ability of BioTime's proprietary HyStem^® drug delivery platform to modulate its release over an extended period.

Hystem^® is BioTime's proprietary hydrogel platform that is designed to facilitate the delivery of cells and molecules. When delivering molecules, it can slowly release the compound in the target area over an extended period of time potentially providing several advantages such as longer term therapeutic benefit. The delivery of cells and molecules is a core area of focus for BioTime. "The data being presented is encouraging and allows BioTime to further explore potential disease modifying therapies for the treatment of osteoarthritis," said Dr. Zarembinski, Head of External R&D for BioTime.

About BioTime, Inc.

BioTime is a clinical-stage biotechnology company focused on degenerative diseases. Its clinical programs are based on two platform technologies: cell replacement and cell/drug delivery. With its cell replacement platform, BioTime is producing new cells and tissues with its proprietary pluripotent cell technologies. These cells and tissues are developed to replace those that are either rendered dysfunctional or lost due to degenerative diseases or injuries. BioTime's cell/drug delivery programs are based upon its proprietary HyStem^® cell and drug delivery hydrogel matrix technology. HyStem^® was designed, in part, to provide for the transfer, retention and/or engraftment of cellular replacement therapies. HyStem^® is a unique hydrogel that has been shown to support cellular attachment and proliferation in vivo. Current research at leading medical institutions has shown that HyStem^® is compatible with a wide variety of cells and tissue types including brain, bone, skin, cartilage, vascular and heart tissues. Due to the unique cross-linking chemistry, HyStem^® hydrogels have the ability to mix cells, biologics and small molecule drugs and can be injected or applied as a gel which allows the hydrogel to conform to a cavity or space. This property of HyStem^® hydrogels offers several distinct advantages over other hydrogels, including the possibility of combining bioactive materials with the hydrogel at the point of use. BioTime is also developing HyStem^® for the delivery of therapeutic drugs and cells to localized areas of the body, including for sustained drug release in the targeted anatomical sites. BioTime's lead cell delivery clinical program is Renevia^®, which consists of HyStem^® combined with the patient's own adipose (fat) derived tissue or cells. Renevia^® met its primary endpoint in an EU pivotal clinical trial for the treatment of facial lipoatrophy in HIV patients in 2017. BioTime has submitted Renevia^® for CE Mark approval in the EU. There were no device related serious adverse events reported to date. BioTime's lead cell replacement product candidate is OpRegen^®, a retinal pigment epithelium transplant therapy, which is in a Phase I/IIa multicenter clinical trial for the treatment of dry age-related macular degeneration, the leading cause of blindness in the developed world. There have been no unexpected serious adverse events reported to date. BioTime also has significant equity holdings in two publicly traded companies, Asterias Biotherapeutics, Inc. AST and OncoCyte Corporation OCX, and a private company, AgeX Therapeutics, Inc.

BioTime common stock is traded on the NYSE American and TASE under the symbol BTX. For more information, please visit www.biotime.com or connect with the company on Twitter, LinkedIn, Facebook, YouTube, and Google+.

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