Aquinox Pharmaceuticals Phase 2 KINSHIP Trial With AQX-1125 in Patients With Atopic Dermatitis Fails to Demonstrate Efficacy

Aquinox Pharmaceuticals, Inc. ("Aquinox")

announced Monday, its Phase 2 KINSHIP clinical trial failed to demonstrate efficacy in patients with mild to moderate atopic dermatitis. "We believe that KINSHIP was well conducted and the results do not warrant continued development for this indication," said David Main, President & CEO at Aquinox. "Given the results of our LEADERSHIP trial, our focus will continue to be on the further development of AQX-1125 in bladder pain syndrome/interstitial cystitis (BPS/IC). To this end, we are looking forward to our end-of-Phase 2 meeting with the United States Food and Drug Administration scheduled for December 8, 2015 to discuss pivotal trial designs." The KINSHIP trial was a multicenter, randomized, double-blind, placebo-controlled, Phase 2 clinical trial investigating the ability of AQX-1125 to reduce characteristic symptoms in 54 patients with mild to moderate atopic dermatitis. Patients treated with 200 mg oral, once daily AQX-1125, compared to placebo, did not meet the primary endpoint of improvement from baseline in Total Lesion Symptom Score after 12 weeks of treatment.