Phase 3 Study Shows Empagliflozin Significantly Reduced Blood Glucose in Adults with Type 2 Diabetes, Impaired Kidney Function

Boehringer Ingelheim Pharmaceuticals and Eli Lilly

today announced results of a 52-week phase III clinical trial of the investigational agent empagliflozin*, which showed statistically significant reductions in HbA1c (average blood glucose) at week 24 with the addition of empagliflozin to existing oral antihyperglycemic therapy in adults with type 2 diabetes (T2D) and mild to moderate kidney impairment (eGFR>/=60 to <90 ml/min/1.73 m2 and eGFR>/=30 to <60 ml/min/1.73 m2).1 Empagliflozin is a member of the sodium glucose co-transporter-2 (SGLT2) inhibitor class of compounds, and is being investigated for the reduction of blood glucose levels in adults with T2D. The emerging SGLT2 inhibitor class removes excess glucose through the urine by blocking glucose re-absorption by the kidney.