GeoVax's Next-Gen Single Dose COVID-19 Vaccine Shows Promising Results

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  • GeoVax Labs Inc GOVX announced the presentation of updates on developing its next-generation COVID-19 vaccine, GEO-CM04S1, including preliminary data from an ongoing Phase 2 trial.
  • The data were presented at the Vaccines Summit Boston 2023 and the Congress for the International Society for the Advancement of Cytometry 2023 meetings.
  • The preliminary analysis indicated CM04S1 is highly immunogenic, inducing both antibody responses, including neutralizing antibodies and T cell responses.
  • These data support the planned progression of the Phase 2 study, which includes a direct comparison to currently approved mRNA vaccines.
  • CM04S1 continues to advance in a second Phase 2 trial as a booster for healthy patients who have previously received the Pfizer Inc PFE or Moderna Inc MRNA mRNA vaccine. 
  • Data from these studies will form the basis for comparing vaccine potential in unique patient groups and the general population.
  • CM04S1 is a next-generation COVID-19 vaccine based on GeoVax's MVA viral vector platform, which supports the presentation of multiple vaccine antigens to the immune system in a single dose. 
  • CM04S1 presents both the spike and nucleocapsid antigens of SARS-CoV-2 and is specifically designed to induce antibody and T-cell responses to non-variable parts of the virus.
  • Based on data from animal models and a completed Phase 1 study, vaccine-induced immune responses were shown to recognize both early and later variants, including the Omicron variant.
  • Vaccines of this format should not require repeated modification and updating.
  • Price Action: GOVX shares are up 4.22% at $0.69 on the last check Wednesday.
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