AstraZeneca's Immunotherapy Imfinzi Shows Improvement In Survival Chances In Lung Cancer Patients

  • In a trial, lung cancer patients treated with AstraZeneca plc's AZN immunotherapy Imfinzi (durvalumab) pre- and post-surgery lived significantly longer without the disease progressing or recurring than those treated with chemotherapy.
  • The late-stage study compared patients with resectable, early-stage, non-small cell lung cancer treated with Imfinzi and chemotherapy before surgery and as monotherapy after surgery to patients treated with chemotherapy pre-surgery.
  • Topline results from a planned interim analysis of the AEGEAN Phase 3 study showed that Imfinzi plus neoadjuvant chemotherapy before surgery and as adjuvant monotherapy after surgery demonstrated a statistically significant and clinically meaningful improvement in event-free survival versus neoadjuvant chemotherapy alone.
  • Related: AstraZeneca Drug Imfinzi Fails As Monotherapy In Metastatic Lung Cancer Setting.
  • Results from the final pathologic complete response and major pathologic response analyses were consistent with previously announced results
  • The trial will continue to assess key secondary endpoints, including disease-free survival (DFS) and overall survival (OS).
  • Imfinzi was well tolerated, and there were no new safety concerns before and after surgery, AstraZeneca said.
  • Price Action: AZN shares are up 1.51% at $65.10 during the premarket session on the last check Thursday.
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