Aeterna Zentaris Shelves Early-Stage Vaccine Programs, Including COVID-19

  • Aeterna Zentaris Inc AEZS has decided to streamline development programs by discontinuing its early-stage vaccine programs.
  • The company worked on evaluating administration routes, dosing, and immunization scheme and conducted in-vivo immunology experiments with candidate strains expressing various antigens in relevant mice models. To date, the company has not been able to select a clinical development candidate for a COVID-19 vaccine.
  • Also, the COVID-19 vaccine landscape has evolved profoundly over the past two years. Aeterna has decided that it will not pursue further development of the vaccine platform for either COVID-19 or Chlamydia (based on the same vaccine platform used in its COVID-19 program). 
  • As a result, the company has also elected to terminate its license agreements with the University of Wuerzburg for vaccine platform technology.
  • The streamlined operations allow the company to meet its currently anticipated cash needs into 2025.
  • In August 2022, Aeterna Zentaris announced that Novo Nordisk A/S NVO terminated the amended development and commercialization license agreement for Macrilen (macimorelin), an oral test indicated for the diagnosis of adult growth hormone deficiency. 
  • Aeterna Zentaris said it is progressing its efforts to seek an alternate development and commercialization partner for Macrilen.
  • Price Action: AEZS shares are trading higher by 3.18% at $3.89 on the last check Tuesday.
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