Lantern Pharma Touts Encouraging Positive Efficacy For Pancreatic Cancer Candidate

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  • Lantern Pharma Inc LTRN will present preclinical data on the in vivo efficacy of its drug candidate LP-184 for pancreatic cancer at the American Association for Cancer Research Special Conference.
  • LP-184 is a small molecule drug candidate and next-generation acylfulvene that preferentially damages DNA in cancer cells harboring mutations in DNA damage repair (DDR) genes and overexpressing the enzyme PTGR1. 
  • Pancreatic cancer cells are expected to be sensitive to LP-184 treatment, as around 25% of these cancers harbor elevated levels of PTGR1 and mutations in DDR genes.
  • After two rounds of LP-184 treatment, the ATR and BRCA1 pancreatic cancer mouse models had tumor growth inhibitions of 140% and 112%, respectively. LP-184 treatment was generally well-tolerated in these mice, and minimal differences were observed in body weight and blood counts relative to treatment control groups.
  • The AACR presentation will show additional data demonstrating that LP-184 can act synergistically in vitro and in vivo with several standard-of-care or FDA-approved agents.
  • These results demonstrate LP-184's potential as a therapeutic agent for pancreatic cancer as a monotherapy or combination with other approved therapies.
  • The company expects a targeted IND submission for LP-184 in Q1 2023 and Phase 1 clinical trials to commence in Q2 2023.
  • Price Action: LTRN shares are up 9.09% at $5.52 on the last check Wednesday.
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