Viridian Therapeutics To Test Next-Gen IGF-1R Antibody In Thyroid Eye Disease

Loading...
Loading...

The FDA has signed off Viridian Therapeutics Inc's VRDN investigational new drug (IND) application of VRDN-002. 

  • The Company's next-generation IGF-1R antibody, VRDN-002, is a humanized monoclonal antibody that incorporates half-life extension technology and is designed to support the administration as a convenient, low-volume, subcutaneous (SC) injection for the treatment of thyroid eye disease (TED).
  • The Company will proceed with its planned Phase 1 trial of VRDN-002, a single ascending dose study to explore the safety, tolerability, pharmacokinetics, and pharmacodynamics of VRDN-002 in healthy volunteers. 
  • Data from this Phase 1 trial are expected to be announced in mid-2022 and will inform the feasibility of a low-volume and/or low-frequency SC dosing paradigm for TED patients.
  • The Company is also conducting a Phase 1/2 proof-of-concept trial for VRDN-001, a monoclonal antibody that blocks the IGF-1 receptor with sub-nanomolar potency for thyroid eye disease.
  • Topline data is expected in Q2 2022.
  • Price Action: VRDN shares are trading at 1.91% higher at $18.68 during the market session on the last check Monday.
Market News and Data brought to you by Benzinga APIs
Comments
Loading...
Posted In: BiotechNewsHealth CareSmall CapFDAGeneralBriefsPhase 1 Trial
Benzinga simplifies the market for smarter investing

Trade confidently with insights and alerts from analyst ratings, free reports and breaking news that affects the stocks you care about.

Join Now: Free!

Loading...