Eloxx Shares Slump As Phase 2 Cystic Fibrosis Trial Data Fails To Cheer Investors

  • Eloxx Pharmaceuticals Inc ELOX posted topline results from the monotherapy arms of its Phase 2 trial of ELX-02 in Class 1 cystic fibrosis patients with at least one G542X nonsense allele mutation. 
  • Eloxx delivered one-week ELX-02 data on 12 people with a G542X nonsense mutation who received ELX-02 at 1.5 mg/kg/day.
  • Sweat chloride, a biomarker of cystic fibrosis, fell by 5.4 mmol/L in recipients of ELX-02, causing the trial to meet one of its key secondary endpoints. 
  • However, there was no change in lung function as measured by FEV1. 
  • Eloxx attributed the missed FEV1 secondary endpoint to the short duration of the clinical trial. 
  • The primary endpoints looked at safety and pharmacokinetics.
  • Eloxx said other groups did show short-term reductions in sweat chloride translate to long-term improvements in lung function. 
  • Eloxx has begun dosing in a Phase 2 expansion arm, evaluating ELX-02 in combination with Vertex Pharmaceuticals Incorporated's VRTX Kalydeco, putting it on course to deliver data in 1H of 2022.
  • Related Link: Eloxx Stock Moves Higher On Fast Track Tag For Cystic Fibrosis Candidate.
  • Price Action: ELOX shares are down 16% at $0.99 during the market session on the last check Wednesday.
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