Immunocore Tebentafusp Shows Survival Benefit In Untreated Eye Cancer Patients

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  • Immunocore Holdings Plc IMCR announced that data from a Phase 3 randomized trial comparing tebentafusp (IMCgp100) with investigator's choice in first-line metastatic uveal melanoma (mUM) had been published in The New England Journal of Medicine.
  • The paper concluded that tebentafusp is the first systemic treatment to show a survival benefit in mUM (eye cancer) and should become a new treatment option.
  •  Results demonstrated a statistically significant and clinically meaningful improvement in overall survival (OS). 
  • The OS Hazard Ratio (HR) in the intent-to-treat population favored tebentafusp, HR=0.51 over investigator's choice (82% pembrolizumab; 12% ipilimumab; 6% dacarbazine). 
  • Treatment-related adverse events were manageable and consistent with the proposed mechanism.
  • Tebentafusp has been granted Breakthrough Therapy Designation, Fast Track designation, and orphan drug designation by the FDA and Promising Innovative Medicine designation in the U.K. for the same indication.
  • Price Action: IMCR stock closed at $35.97 on Wednesday.
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Posted In: BiotechNewsHealth CareSmall CapGeneralBriefseye cancerPhase 3 Trial
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