- Progenity Inc PROG has announced results from a preclinical study evaluating the delivery of PGN-001 (adalimumab liquid formulation) drug substance directly to the colon in an animal model of induced colitis.
- Adalimumab is the active ingredient used in AbbVie Inc's ABBV flagship rheumatoid arthritis med, Humira.
- The study found that adalimumab was detected in tissue along the length of the colon.
- Also, a significant reduction in TNF-α, the proinflammatory cytokine target of adalimumab, at every 24 and 48 hours following repeat doses were observed compared with the untreated induced colitis control group.
- No treatment-related adverse events were observed, and no measurable adalimumab was detected in the blood.
- Progenity's Targeted Therapeutics program consists of drug-device combination products designed to maximize the available dose at the disease site to improve efficacy and potentially reduce systemic toxicity.
- The company is currently performing a clinical study to obtain further supporting data for the local delivery of adalimumab, using administration by enema as a surrogate for delivery with the Drug Delivery System (DDS).
- Preliminary results are expected in 2021.
- Price Action: PROG shares are down 0.41% at $2.41 during the premarket session on the last check Wednesday.
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