What's Hot on TheStreet

Here's what Benzinga's reading on our friend,

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Biotech investors looking for outsized returns in 2010 failed to find them in "Big Five" large-cap biotech stocks. Only Genzyme

and Biogen Idec

yielded double-digit returns over the past 12 months, the former boosted by Sanofi-Aventis'

takeover efforts and the latter helped by an earnings boost stemming more from cost-cutting and drug price hikes than top-line sales growth.

Carl Icahn revealed on Monday that he had increased his stake in Chesapeake

to more than 5.8%. This caused a fast $2 rise in the shares of the stock, benefiting Icahn's stake alone to the tune of more than $70 million.

American International Group

shares are hitting highs not seen since October 2008, as investors prepare for potential upside as the government begins selling off its 92% stake in the firm.

Bank of America

shares opened higher on Wednesday despite a flurry of negative news reports.