Alnylam Pharmaceuticals Stock (NASDAQ: ALNY)

Alnylam Pharmaceuticals (NASDAQ:ALNY) Stock, Quote.Headers.trade-ideas

Alnylam Pharmaceuticals

Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.

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Shares of Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY) were down 8.5% on Aug. 30, after the company announced detailed data from the phase III HELIOS-B, which evaluated its investigational RNAi therapeutic, Amvuttra (vutrisiran) for an expanded indication.

ALNY Down Despite Positive Data From Heart Disease Drug Study

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Alnylam Pharmaceuticals shares drop as detailed results from the HELIOS-B Phase 3 study of vutrisiran for ATTR-CM reveal mixed outcomes. Reductions in mortality and cardiovascular events were presented at ESC Congress 2024. Regulatory submissions remain on track.

Alnylam Pharmaceuticals Stock Falls After Detailed Vutrisiran Data For A Condition With Stiff Heart Muscles

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Top 10 stocks with highest gains last week, including Exact Sciences, Alnylam Pharmaceuticals, Resmed, Coca-Cola Consolidated, DexCom, Sprouts Farmers Market, UL Solutions, Labcorp Holdings, C.H. Robinson Worldwide, and DoorDash.

DoorDash And Exact Sciences Are Among Top 10 Large Cap Gainers Last Week (July 28-Aug 3): Are The Others In Your Portfolio?

Alnylam Pharmaceuticals, Inc. - Common Stock

Alnylam Pharmaceuticals Inc

ALNYLAM PHARMACEUTICALS ORD

Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) has outperformed the market over the past 10 years by 3.01% on an annualized basis producing an average annual return of 13.61%. Currently, Alnylam Pharmaceuticals has a market capitalization of $32.89 billion. 
Buying $1000 In ALNY: If an investor had bought $1000 of ALNY stock 10 years ago, it would be worth $3,656.71 today based on a price of $256.21 for ALNY at the time of writing.
<h3>Alnylam Pharmaceuticals's Performance Over Last 10 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1726075837_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much You Would Have Made Owning Alnylam Pharmaceuticals Stock In The Last 10 Years

Cantor Fitzgerald analyst Olivia Brayer reiterates Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) with a Neutral and maintains $220 price target.

Price Target

Reiteration

Cantor Fitzgerald Reiterates Neutral on Alnylam Pharmaceuticals, Maintains $220 Price Target

RBC Capital analyst Luca Issi reiterates Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) with a Outperform and maintains $300 price target.

RBC Capital Reiterates Outperform on Alnylam Pharmaceuticals, Maintains $300 Price Target

B of A Securities analyst Tazeen Ahmad maintains Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) with a Buy and raises the price target from $295 to $307.

B of A Securities Maintains Buy on Alnylam Pharmaceuticals, Raises Price Target to $307

Shares of Alnylam Pharmaceuticals, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/alny#NASDAQ">ALNY</a>) were down 8.5% on Aug. 30, after the company announced detailed data from the phase III HELIOS-B, which evaluated its investigational RNAi therapeutic, Amvuttra (vutrisiran) for an expanded indication.
The HELIOS-B study is seeking to expand the label of Amvuttra for the treatment of transthyretin-mediated (ATTR) amyloidosis with cardiomyopathy.
Per the company, the HELIOS-B study met the primary endpoint, demonstrating a statistically significant reduction in the composite of all-cause mortality and recurrent cardiovascular events in the overall population as well as the monotherapy population.
However, as a component of the primary endpoint, treatment with vutrisiran led to a 30% reduction in mortality in the monotherapy population in the double-blind period. Per management, this reduction was non-significant.
This might have hurt investors&#39; sentiments and resulted in the stock going down.
<h2>ALNY Stock Outperforming Industry</h2>
Shares of Alnylam have gained 37.3% so far this year compared with the industry&#39;s growth of 0.6%.
<img alt="Zacks Investment Research" src="https://staticx-tuner.zacks.com/images/articles/charts/42/76266.jpg?v=875498674" />
Image Source: Zacks Investment Research
Please note that vutrisiran is already approved in the United States for the treatment of adult patients with polyneuropathy of hereditary ATTR amyloidosis. This is also approved in the European Union for the same indication in adult patients with stage 1 or stage 2 polyneuropathy. Vutrisiran is marketed under the trade name Amvuttra in the United States and Europe.
In June 2024, Alnylam reported encouraging data from the phase III HELIOS-B study evaluating vutrisiran for the treatment of patients with ATTR amyloidosis with cardiomyopathy. Shares of the company soared on this news.
The phase III HELIOS-B study enrolled 655 adult patients with ATTR amyloidosis (hereditary or wild-type) with cardiomyopathy who were divided equally to receive vutrisiran 25mg or placebo subcutaneously once every three months for up to 36 months.
Alnylam is gearing up to proceed with global regulatory submissions, including filing a supplemental new drug application for vutrisiran with the FDA using a Priority Review Voucher later in 2024.
<h2>Amvuttra, a Key Revenue Driver for ALNY</h2>
Amvuttra is currently the top contributor to Alnylam&#39;s top line. This drug generated sales worth $425.4 million in the first half of 2024, increasing 82% year over year on a reported basis. The encouraging uptake of the drug is driven by new patients starting treatment as well as patients switching from ALNY&#39;s Onpattro(patisiran).
Onpattro is also approved in the United States and European Union to treat ATTR amyloidosis in adults.
If approved forthe new indication, Alnylam believes that vutrisiran has the potential to become the new standard of care for the treatment of ATTR amyloidosis with cardiomyopathy. This is likely to boost sales further and will expand the eligible patient population for the drug in future quarters.
<h2>Zacks Rank &amp; Stocks to Consider</h2>
Alnylam currently carries a Zacks Rank #3 (Hold).
Some better-ranked stocks in the biotech sector are Illumina, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/ilmn#NASDAQ">ILMN</a>), Krystal Biotech, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/krys#NASDAQ">KRYS</a>) and Fulcrum Therapeutics, Inc. (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/fulc#NASDAQ">FULC</a>), each sporting a Zacks Rank #1 (Strong Buy) at present.
In the past 60 days, estimates for Illumina&#39;s 2024 earnings per share have moved up from $1.18 to $3.62. Earnings per share estimates for 2025 have improved from $2.93 to $4.50. Year to date, shares of ILMN have lost 5.6%.
ILMN&#39;s earnings beat estimates in each of the trailing four quarters, the average surprise being 463.46%.
In the past 60 days, estimates for Krystal Biotech&#39;s 2024 earnings per share have increased from $1.98 to $2.38. Earnings per share estimates for 2025 have improved from $4.33 to $7.31. Year to date, shares of KRYS have risen 57.3%.
KRYS&#39; earnings beat estimates in three of the trailing four quarters while missing on the remaining occasion, the average surprise being 45.95%.
In the past 60 days, estimates for Fulcrum Therapeutics&#39; 2024 loss per share have narrowed from $1.24 to 48 cents. Loss per share estimates for 2025 have narrowed from $1.71 to $1.51. Year to date, shares of FULC have jumped 26.7%.
FULC&#39;s earnings beat estimates in each of the trailing four quarters, the average surprise being 393.18%.
<a href="https://www.zacks.com/stock/news/2330592/alny-down-despite-positive-data-from-heart-disease-drug-study?cid=CS-BENZ-FT-analyst_blog|company_news_medical_sector-2330592">To read this article on Zacks.com click here.</a>

<h3>Gainers</h3>
<ul>
<li>Theriva Biologics (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/TOVX#AMEX">TOVX</a>) shares moved upwards by 34.2% to $6.31 during Monday's pre-market session. The market value of their outstanding shares is at $6.3 million. </li>
<li>Emergent BioSolutions (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EBS#NYSE">EBS</a>) shares rose 17.62% to $10.48. The market value of their outstanding shares is at $549.1 million. </li>
<li>LogicMark (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LGMK#NASDAQ">LGMK</a>) stock moved upwards by 14.96% to $0.19. The market value of their outstanding shares is at $2.2 million. </li>
<li>Synaptogenix (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SNPX#NASDAQ">SNPX</a>) stock increased by 14.95% to $4.06. The market value of their outstanding shares is at $5.3 million. </li>
<li>Milestone Scientific (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/MLSS#AMEX">MLSS</a>) shares moved upwards by 11.9% to $1.08. The market value of their outstanding shares is at $83.4 million. </li>
<li>Biomea Fusion (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BMEA#NASDAQ">BMEA</a>) shares moved upwards by 11.41% to $8.49. The company's market cap stands at $307.4 million. </li>
</ul>
<h3>Losers</h3>
<ul>
<li>NuCana (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NCNA#NASDAQ">NCNA</a>) shares declined by 48.3% to $4.0 during Monday's pre-market session. The market value of their outstanding shares is at $9.0 million. </li>
<li>Catheter Precision (AMEX:<a class="ticker" href="https://www.benzinga.com/stock/VTAK#AMEX">VTAK</a>) shares declined by 27.95% to $0.98. </li>
<li>Ekso Bionics Holdings (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EKSO#NASDAQ">EKSO</a>) stock declined by 15.18% to $0.95. The company's market cap stands at $17.5 million. </li>
<li>Nutex Health (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NUTX#NASDAQ">NUTX</a>) shares decreased by 7.69% to $20.18. The market value of their outstanding shares is at $102.2 million. </li>
<li>Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) shares fell 7.5% to $265.51. The market value of their outstanding shares is at $34.0 billion. </li>
<li>Exicure (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XCUR#NASDAQ">XCUR</a>) shares declined by 6.42% to $1.75. The market value of their outstanding shares is at $3.0 million. 
See Also: <a href="http://www.benzinga.com/money/best-healthcare-stocks/" title="www.benzinga.com/money/best-healthcare-stocks/">www.benzinga.com/money/best-healthcare-stocks/</a></li>
</ul>
This article was generated by Benzinga's automated content engine and reviewed by an editor.

BMEA

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12 Health Care Stocks Moving In Monday's Pre-Market Session

Investors with a lot of money to spend have taken a bullish stance on Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>).
And retail traders should know.
We noticed this today when the trades showed up on publicly available options history that we track here at Benzinga.
Whether these are institutions or just wealthy individuals, we don't know. But when something this big happens with ALNY, it often means somebody knows something is about to happen.
So how do we know what these investors just did? 
Today, <a href="https://pro.benzinga.com/?utm_source=insights">Benzinga</a>'s options scanner spotted 19 uncommon options trades for Alnylam Pharmaceuticals.
This isn't normal.
The overall sentiment of these big-money traders is split between 36% bullish and 31%, bearish.
Out of all of the special options we uncovered, 12 are puts, for a total amount of $1,479,365, and 7 are calls, for a total amount of $532,783.
<h3>Projected Price Targets</h3>
Based on the trading activity, it appears that the significant investors are aiming for a price territory stretching from $90.0 to $310.0 for Alnylam Pharmaceuticals over the recent three months. 
<h3>Analyzing Volume &amp; Open Interest</h3>
In terms of liquidity and interest, the mean open interest for Alnylam Pharmaceuticals options trades today is 608.25 with a total volume of 5,819.00.
In the following chart, we are able to follow the development of volume and open interest of call and put options for Alnylam Pharmaceuticals's big money trades within a strike price range of $90.0 to $310.0 over the last 30 days.
<h3>Alnylam Pharmaceuticals Option Activity Analysis: Last 30 Days</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1725049066_0.png" alt="Options Call Chart" />
<h3>Noteworthy Options Activity:</h3>

<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Ask</th>
<th>Bid</th>
<th>Price</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th style="text-align: right;">Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>ALNY</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>01/17/25</td>
<td>$20.4</td>
<td>$18.2</td>
<td>$18.3</td>
<td>$260.00</td>
<td>$915.0K</td>
<td>70</td>
<td style="text-align: right;">500</td>
</tr>
<tr>
<td>ALNY</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>12/20/24</td>
<td>$177.5</td>
<td>$173.9</td>
<td>$173.9</td>
<td>$90.00</td>
<td>$173.9K</td>
<td>0</td>
<td style="text-align: right;">10</td>
</tr>
<tr>
<td>ALNY</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>09/20/24</td>
<td>$14.8</td>
<td>$14.7</td>
<td>$14.7</td>
<td>$270.00</td>
<td>$151.4K</td>
<td>2.7K</td>
<td style="text-align: right;">323</td>
</tr>
<tr>
<td>ALNY</td>
<td>PUT</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>09/20/24</td>
<td>$22.6</td>
<td>$19.5</td>
<td>$22.0</td>
<td>$280.00</td>
<td>$110.0K</td>
<td>412</td>
<td style="text-align: right;">88</td>
</tr>
<tr>
<td>ALNY</td>
<td>CALL</td>
<td>SWEEP</td>
<td>NEUTRAL</td>
<td>10/18/24</td>
<td>$21.0</td>
<td>$19.5</td>
<td>$20.99</td>
<td>$250.00</td>
<td>$103.9K</td>
<td>0</td>
<td style="text-align: right;">57</td>
</tr>
</tbody>
</table>

<h3>About Alnylam Pharmaceuticals</h3>
Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.
<h3>Present Market Standing of Alnylam Pharmaceuticals</h3>
<ul>
<li>Currently trading with a volume of 3,753,765, the ALNY's price is down by -8.47%, now at $262.69. </li>
<li>RSI readings suggest the stock is currently is currently neutral between overbought and oversold.</li>
<li>Anticipated earnings release is in 62 days.</li>
</ul>
<h3>What The Experts Say On Alnylam Pharmaceuticals</h3>
In the last month, 5 experts released ratings on this stock with an average target price of $264.2.
<ul>
<li>Maintaining their stance, an analyst from Wells Fargo continues to hold a Equal-Weight rating for Alnylam Pharmaceuticals, targeting a price of $233. </li>
<li>An analyst from Needham persists with their Buy rating on Alnylam Pharmaceuticals, maintaining a target price of $320. </li>
<li>An analyst from Goldman Sachs has decided to maintain their Neutral rating on Alnylam Pharmaceuticals, which currently sits at a price target of $198. </li>
<li>An analyst from Raymond James has decided to maintain their Outperform rating on Alnylam Pharmaceuticals, which currently sits at a price target of $275. </li>
<li>An analyst from Barclays persists with their Overweight rating on Alnylam Pharmaceuticals, maintaining a target price of $295. </li>
</ul>
Trading options involves greater risks but also offers the potential for higher profits. Savvy traders mitigate these risks through ongoing education, strategic trade adjustments, utilizing various indicators, and staying attuned to market dynamics. Keep up with the latest options trades for Alnylam Pharmaceuticals with <a href="https://benzinga.grsm.io/register174">Benzinga Pro</a> for real-time alerts.

Options

Market Whales and Their Recent Bets on ALNY Options

HC Wainwright &amp; Co. analyst Patrick Trucchio reiterates Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) with a Buy and maintains $400 price target.

HC Wainwright & Co. Reiterates Buy on Alnylam Pharmaceuticals, Maintains $400 Price Target

Friday, Alnylam Pharmaceuticals Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) stock is trading lower after the company shared detailed results from the HELIOS-B Phase 3 study of vutrisiran for ATTR amyloidosis with cardiomyopathy (ATTR-CM). Topline data was <a target="_blank" href="https://www.benzinga.com/general/biotech/24/06/39456940/alnylams-closely-watched-phase-3-heart-disease-trial-of-vutrisiran-hits-primary-endpoint-shares-s" rel="noreferrer noopener">revealed in June</a>.
The data were presented at the European Society of Cardiology Congress 2024.
Also Read: <a target="_blank" href="https://www.benzinga.com/analyst-ratings/analyst-color/24/03/37491686/rochealnylam-blood-pressure-drug-aces-in-mid-stage-trial-analyst-says-zilebesiran-a" rel="noreferrer noopener">Roche/Alnylam Blood Pressure Drug Aces In Mid-Stage Trial, Analyst Says Zilebesiran As Promising Opportunity In Addressing Global Hypertension Challenges</a>.
In the overall population, vutrisiran reduced the risk of all-cause mortality and recurrent cardiovascular events by 28%, with similar reductions in the mortality and cardiovascular <a target="_blank" href="https://www.benzinga.com/pressreleases/24/08/b40647186/alnylam-presents-detailed-results-from-the-positive-helios-b-phase-3-study-of-vutrisiran-in-patien" rel="noreferrer noopener">events components of the endpoint</a>.
Mortality in this population was significantly reduced by 31% and by 36% up to 42 months.
In the monotherapy population, vutrisiran reduced the risk of all-cause mortality and recurrent cardiovascular events by 33% and reduced the risk of mortality by 35% up to 42 months.
A non-significant reduction of 30% in mortality was observed (nominal p-value 0.1179) in the monotherapy population.
Vutrisiran treatment was also associated with benefits versus placebo across multiple well-established clinical measures of disease progression.
At the ESC congress, Alnylam said that at month 30, patients on vutrisiran experienced a decline in 6-MWT of 26.46 meters from baseline, while 32.09 meters for the placebo arm.
Subgroup analyses of the primary and secondary endpoints demonstrated generally consistent results across all key patient segments, including patients receiving Pfizer Inc&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>) Vyndamax (tafamidis)&nbsp;at baseline.
In patients receiving baseline tafamidis, vutrisiran demonstrated a 22% reduction in the composite primary endpoint of ACM and recurrent CV events and a 41% reduction in ACM at 42 months versus placebo.
Trends toward greater than average benefit were seen in patients with baseline characteristics indicative of early disease.
The company remains on track to proceed with global regulatory submissions for vutrisiran starting later this year, including filing a supplemental New Drug Application with the FDA using a Priority Review Voucher.
BridgeBio Pharma Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BBIO#NASDAQ">BBIO</a>) has ATTR-CM therapy acoramidis, currently&nbsp;under FDA priority review with an FDA action <a target="_blank" href="https://www.benzinga.com/pressreleases/24/02/g36930111/bridgebio-pharma-announces-u-s-food-and-drug-administration-fda-acceptance-of-new-drug-application" rel="noreferrer noopener">date of November 29</a>. BridgeBio Pharma stock jumped&nbsp;in reaction.
Price Action: ALNY stock is down 5.9% at $270.00 at last check Friday.
Photo via Shutterstock
Read Next:
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<li><a href="https://www.benzinga.com/m-a/24/08/40650305/secureworks-stock-drops-as-dell-weighs-strategic-sale-options" target="_blank" rel="noreferrer noopener">SecureWorks Stock Drops as Dell Weighs Strategic Sale Options</a>.</li>
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Alnylam Says Typo In Presentation Misstated Heart Drug Benefit

WIIM

Alnylam Pharmaceuticals shares are trading lower. The company announced results from its HELIOS-B Phase 3 study of vutrisiran, an investigational RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy.

Alnylam Presents Detailed Results From Positive HELIOS-B Phase 3 Study Of Vutrisiran: Achieved 28% Reduction In Primary Composite Of All-cause Mortality And Recurrent Cardiovascular Events, And 31% And 36% Reductions In All-cause Mortality

Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) has outperformed the market over the past 5 years by 13.34% on an annualized basis producing an average annual return of 27.24%. Currently, Alnylam Pharmaceuticals has a market capitalization of $34.55 billion. 
Buying $100 In ALNY: If an investor had bought $100 of ALNY stock 5 years ago, it would be worth $326.67 today based on a price of $269.14 for ALNY at the time of writing.
<h3>Alnylam Pharmaceuticals's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1724706021_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

$100 Invested In This Stock 5 Years Ago Would Be Worth $300 Today

JP Morgan analyst Jessica Fye maintains Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) with a Neutral and raises the price target from $248 to $280.

JP Morgan Maintains Neutral on Alnylam Pharmaceuticals, Raises Price Target to $280

Goldman Sachs analyst Salveen Richter upgrades Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) from Neutral to Buy and raises the price target from $198 to $370.

Upgrades

Goldman Sachs Upgrades Alnylam Pharmaceuticals to Buy, Raises Price Target to $370

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders will search for circumstances when the market estimation of an option diverges heavily from its normal worth. High amounts of trading activity could push option prices to exaggerated or underestimated levels. 
Below are some instances of options activity happening in the Health Care sector: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th style="text-align: right;">Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>MDGL</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>10/18/24</td>
<td>$340.00</td>
<td>$218.4K</td>
<td>641</td>
<td style="text-align: right;">626</td>
</tr>
<tr>
<td>NVO</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>09/13/24</td>
<td>$138.00</td>
<td>$77.5K</td>
<td>0</td>
<td style="text-align: right;">381</td>
</tr>
<tr>
<td>MRNA</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>12/18/26</td>
<td>$80.00</td>
<td>$729.7K</td>
<td>48</td>
<td style="text-align: right;">358</td>
</tr>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>09/20/24</td>
<td>$900.00</td>
<td>$72.7K</td>
<td>980</td>
<td style="text-align: right;">296</td>
</tr>
<tr>
<td>ELV</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>08/16/24</td>
<td>$520.00</td>
<td>$26.9K</td>
<td>158</td>
<td style="text-align: right;">104</td>
</tr>
<tr>
<td>IOVA</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>01/16/26</td>
<td>$5.00</td>
<td>$64.0K</td>
<td>3.0K</td>
<td style="text-align: right;">100</td>
</tr>
<tr>
<td>VKTX</td>
<td>CALL</td>
<td>TRADE</td>
<td>NEUTRAL</td>
<td>11/15/24</td>
<td>$70.00</td>
<td>$41.7K</td>
<td>2.0K</td>
<td style="text-align: right;">61</td>
</tr>
<tr>
<td>MCK</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>02/21/25</td>
<td>$590.00</td>
<td>$37.3K</td>
<td>1</td>
<td style="text-align: right;">28</td>
</tr>
<tr>
<td>ARGX</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>12/20/24</td>
<td>$530.00</td>
<td>$36.5K</td>
<td>2</td>
<td style="text-align: right;">25</td>
</tr>
<tr>
<td>ALNY</td>
<td>CALL</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>08/16/24</td>
<td>$240.00</td>
<td>$70.0K</td>
<td>609</td>
<td style="text-align: right;">21</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These bullet-by-bullet explanations have been constructed using the accompanying table. 
• For MDGL (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MDGL#NASDAQ">MDGL</a>), we notice a call option trade that happens to be bullish, expiring in 67 day(s) on October 18, 2024. This event was a transfer of 624 contract(s) at a $340.00 strike. The total cost received by the writing party (or parties) was $218.4K, with a price of $350.0 per contract. There were 641 open contracts at this strike prior to today, and today 626 contract(s) were bought and sold. 
• For NVO (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>), we notice a call option trade that happens to be bullish, expiring in 32 day(s) on September 13, 2024. This event was a transfer of 380 contract(s) at a $138.00 strike. The total cost received by the writing party (or parties) was $77.5K, with a price of $204.0 per contract. There were 0 open contracts at this strike prior to today, and today 381 contract(s) were bought and sold. 
• Regarding MRNA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MRNA#NASDAQ">MRNA</a>), we observe a put option trade with bullish sentiment. It expires in 858 day(s) on December 18, 2026. Parties traded 350 contract(s) at a $80.00 strike. The total cost received by the writing party (or parties) was $729.7K, with a price of $2085.0 per contract. There were 48 open contracts at this strike prior to today, and today 358 contract(s) were bought and sold. 
• Regarding LLY (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), we observe a call option trade with neutral sentiment. It expires in 39 day(s) on September 20, 2024. Parties traded 20 contract(s) at a $900.00 strike. The total cost received by the writing party (or parties) was $72.7K, with a price of $3639.0 per contract. There were 980 open contracts at this strike prior to today, and today 296 contract(s) were bought and sold. 
• For ELV (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ELV#NYSE">ELV</a>), we notice a put option sweep that happens to be bearish, expiring in 4 day(s) on August 16, 2024. This event was a transfer of 100 contract(s) at a $520.00 strike. This particular put needed to be split into 14 different trades to become filled. The total cost received by the writing party (or parties) was $26.9K, with a price of $272.0 per contract. There were 158 open contracts at this strike prior to today, and today 104 contract(s) were bought and sold. 
• For IOVA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IOVA#NASDAQ">IOVA</a>), we notice a call option trade that happens to be bearish, expiring in 522 day(s) on January 16, 2026. This event was a transfer of 100 contract(s) at a $5.00 strike. The total cost received by the writing party (or parties) was $64.0K, with a price of $640.0 per contract. There were 3010 open contracts at this strike prior to today, and today 100 contract(s) were bought and sold. 
• Regarding VKTX (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VKTX#NASDAQ">VKTX</a>), we observe a call option trade with neutral sentiment. It expires in 95 day(s) on November 15, 2024. Parties traded 50 contract(s) at a $70.00 strike. The total cost received by the writing party (or parties) was $41.7K, with a price of $835.0 per contract. There were 2099 open contracts at this strike prior to today, and today 61 contract(s) were bought and sold. 
• For MCK (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MCK#NYSE">MCK</a>), we notice a call option trade that happens to be bearish, expiring in 193 day(s) on February 21, 2025. This event was a transfer of 14 contract(s) at a $590.00 strike. The total cost received by the writing party (or parties) was $37.3K, with a price of $2670.0 per contract. There were 1 open contracts at this strike prior to today, and today 28 contract(s) were bought and sold. 
• For ARGX (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ARGX#NASDAQ">ARGX</a>), we notice a put option trade that happens to be bullish, expiring in 130 day(s) on December 20, 2024. This event was a transfer of 10 contract(s) at a $530.00 strike. The total cost received by the writing party (or parties) was $36.5K, with a price of $3650.0 per contract. There were 2 open contracts at this strike prior to today, and today 25 contract(s) were bought and sold. 
• Regarding ALNY (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>), we observe a call option trade with bullish sentiment. It expires in 4 day(s) on August 16, 2024. Parties traded 20 contract(s) at a $240.00 strike. The total cost received by the writing party (or parties) was $70.0K, with a price of $3500.0 per contract. There were 609 open contracts at this strike prior to today, and today 21 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more news on unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

ARGX

streetTRACKS Dow Jones U.S. Large Cap Value Index Fund

IOVA

MDGL

MRNA

VKTX

10 Health Care Stocks With Whale Alerts In Today's Session

Alnylam Pharmaceuticals (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NASDAQ">ALNY</a>) has outperformed the market over the past 10 years by 5.17% on an annualized basis producing an average annual return of 15.53%. Currently, Alnylam Pharmaceuticals has a market capitalization of $33.40 billion. 
Buying $100 In ALNY: If an investor had bought $100 of ALNY stock 10 years ago, it would be worth $424.42 today based on a price of $260.17 for ALNY at the time of writing.
<h3>Alnylam Pharmaceuticals's Performance Over Last 10 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1723066215_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Company To Host Conference Call And Investor Webcast On August 30, 2024

Alnylam Pharmaceuticals To Present HELIOS-B Phase 3 Study Results Of Vutrisiran At ESC Congress 2024; Announces Topline Results Demonstrating Significant Reduction In Mortality And Cardiovascular Events

Alnylam Pharmaceuticals's (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ALNY#NYSE">ALNY</a>) short percent of float has risen 22.39% since its last report. The company recently reported that it has 4.49 million shares sold short, which is 4.1% of all regular shares that are available for trading. Based on its trading volume, it would take traders 4.47 days to cover their short positions on average.
<h3>Why Short Interest Matters</h3>
Short interest is the number of shares that have been sold short but have not yet been covered or closed out. <a href="https://www.benzinga.com/money/how-to-short-a-stock/">Short selling</a> is when a trader sells shares of a company they do not own, with the hope that the price will fall. Traders make money from short selling if the price of the stock falls and they lose if it rises.
Short interest is important to track because it can act as an indicator of market sentiment towards a particular stock. An increase in short interest can signal that investors have become more bearish, while a decrease in short interest can signal they have become more bullish.
See Also: <a href="https://www.benzinga.com/short-interest">List of the most shorted stocks</a>
<h3>Alnylam Pharmaceuticals Short Interest Graph (3 Months)</h3>
<img src="https://www.benzinga.com/files/images/story/2024/1722963611_0.png" alt="short_fig" />
As you can see from the chart above the percentage of shares that are sold short for Alnylam Pharmaceuticals has grown since its last report. This does not mean that the stock is going to fall in the near-term but traders should be aware that more shares are being shorted.
<h3>Comparing Alnylam Pharmaceuticals's Short Interest Against Its Peers</h3>
Peer comparison is a popular technique amongst analysts and investors for gauging how well a company is performing. A company's peer is another company that has similar characteristics to it, such as industry, size, age, and financial structure. You can find a company's peer group by reading its 10-K, proxy filing, or by doing your own similarity analysis.
According to <a href="https://pro.benzinga.com/">Benzinga Pro</a>, Alnylam Pharmaceuticals's peer group average for short interest as a percentage of float is 7.27%, which means the company has less short interest than most of its peers.
Did you know that increasing short interest can actually be bullish for a stock? <a href="https://www.benzinga.com/money/how-to-make-money-on-a-short-squeeze/">This post by Benzinga Money explains how you can profit from it.</a>
This article was generated by Benzinga's automated content engine and was reviewed by an editor.

Short Sellers

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How Is The Market Feeling About Alnylam Pharmaceuticals?

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Alnylam Pharma (ALNY – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst yesterday. Analyst Maury Raycroft fr...

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Analyst Tazeen Ahmad from Bank of America Securities reiterated a Buy rating on Alnylam Pharma (ALNY – Research Report) and increased the price tar...

Alnylam Pharma's Vutrisiran Garners Strong Buy Rating Amidst Positive ATTR-CM Treatment Prospects

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Alnylam Pharma (ALNY) Receives a Buy from Bank of America Securities

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Press Releases

Medison Pharma and Alnylam Pharmaceuticals Announce Expansion of their Multi-Regional Partnership in Europe and Israel to Commercialize RNAi Therapeutics in additional LATAM and APAC markets including Australia

Alnylam Pharmaceuticals Reports First Quarter 2024 Financial Results and Highlights Recent Period Activity

Alnylam Issues 2023 Corporate Responsibility Report

Alnylam Reports Positive Topline Results from HELIOS-B Phase 3 Study of Vutrisiran, Achieving Statistical Significance on Primary and All Secondary Endpoints in Both Overall and Monotherapy Populations

Alnylam to Webcast Conference Call Discussing Second Quarter 2024 Financial Results

Alnylam Pharmaceuticals Reports Second Quarter 2024 Financial Results and Highlights Recent Period Activity

Alnylam to Present Detailed Results from the HELIOS-B Phase 3 Study of Vutrisiran▼ in Patients with ATTR Amyloidosis with Cardiomyopathy at the European Society of Cardiology Congress 2024

Alnylam to Webcast Presentations at Upcoming September Investor Conferences

Alnylam Presents Detailed Results from the Positive HELIOS-B Phase 3 Study of Vutrisiran▼ in Patients with ATTR Amyloidosis with Cardiomyopathy at the European Society of Cardiology Congress

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Alnylam Pharmaceuticals (ALNY) Forecast

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