Alma Gold (OTC:ALGLF) Stock, Quote.Headers.trade-ideas

Alma Gold Inc is a Canadian based firm involved in the acquisition and exploration of mineral property assets. The company's project consists of Dialakoro Gold Project, Guinea, Karita Gold Project, Guinea, Clarence Stream North Gold Project, Canada. The Company's exploration operations are carried out principally in Canada and secondarily, Guinea.

Alma Gold Inc

Teva Pharmaceuticals, a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA), today presented data informing clinical strategies for switching patients to UZEDY&#xAE;, an extended-release injectable suspension of risperidone for subcutaneous use every one or two months for the treatment of schizophrenia in adults, from a once-monthly subcutaneous injection of Perseris&#xAE; (RBP-7000). The results were presented during the 37th Annual European College of Neuropsychopharmacology (ECNP) Congress taking place between September 21-24, 2024, in Milan, Italy.
Schizophrenia is a complex medical condition that may require switching from an oral option or between different long-acting injectable options during the patient treatment journey. These data further clinical understanding of optimal treatment strategies when switching to UZEDY from Perseris&#xAE;.
"Schizophrenia patients and healthcare providers rely on evidence-based studies that can help inform their treatment decisions. That is why Teva is dedicated to building on our commitment to neuroscience and schizophrenia and helps provide these clinical insights on UZEDY switching strategies, along with its role in long-acting treatment options," said Eric Hughes, MD, PhD, Executive Vice President of Global R&amp;D and Chief Medical Officer at Teva. "Up to 80% of schizophrenia patients experience multiple relapses in the first five years, making switching treatments a common experience in the search for optimal treatment. With UZEDY, Teva is building a robust portfolio of research that can help determine if and when it may be the right long-acting option."
In a population pharmacokinetic (PopPK) analysis, simulations were conducted to predict pharmacokinetic (PK) exposures when switching to UZEDY 4-6 weeks after the last injection of once-monthly RBP-7000. The simulation models indicated that switching to UZEDY 4 weeks after the last dose of once-monthly RBP-7000 resulted in comparable PK properties of UZEDY at both the initial exposure and steady state. Comparable doses included UZEDY at 100 mg (once-monthly dosing) or 200 mg (once-every-two-months dosing) to 120 mg of once-monthly RBP-7000.1
Any switching strategy should be determined by clinicians on an individual patient basis, considering factors such as patient preference, scheduling convenience and potential tolerability issues or risk of symptom breakthrough.
"Every person living with schizophrenia has unique treatment needs and preferences that may also evolve over time. For my patients, I encourage discussion around key factors like treatment adherence, dosing frequency, symptom control, and rate of relapse which inform what treatment option may be the most appropriate," said Christoph Correll, MD, Professor of Psychiatry at the Zucker School of Medicine, Hempstead, NY. "For healthcare providers, there is also a significant knowledge gap in the available clinical data on switching patients between the various LAI treatment options, which have differing pharmacokinetic properties and dosing considerations. Insights from studies like these are crucial for researchers and clinicians like myself, as they help us become more informed and better serve our patients."
Additional key data being presented at ECNP 2024 included new quantitative results from the ADVANCE (Attitudes Driving Regional Differences in LAI Antipsychotic Utilization for Schizophrenia Among HCPs, Patients and Caregivers) surveys, including:
<ul>
<li>Among 447 people living with schizophrenia and 375 caregivers, most common patient-reported reasons for accepting an LAI (n=331) were improvement of symptoms/condition with LAIs (68%, n=224), recommendation by their HCP (65%, n=214) and ease of using LAIs versus oral antipsychotics (57%, n=189).1</li>
<li>Patients also reported using LAIs due to fewer side effects versus oral antipsychotics (38%, n=127) and to help prevent hospitalization (20%, n=67).1</li>
<li>Caregivers (n=229) reported that patients accepted LAIs based on ease of use versus oral antipsychotics (78%, n=178), to help prevent hospitalization (62%, n=143) and perception that LAIs would work better for improving condition/symptoms (62%, n=143).1</li>
<li>Among a sample of 791 HCPs from 8 different countries, most HCPs reported that the primary reason for recommending an LAI to a patient was nonadherence to oral medication, with the exception of South Korea where the most common reason was that an LAI would be more efficacious than oral.1</li>
<li>The primary reasons cited for not recommending an LAI were patient clinical characteristics and the lack of an available LAI formulation of the patient's current oral treatment, except for China and South Korea, where the primary reasons were LAI cost to patient and LAI product not marketed, respectively.</li>
</ul>

News

TEVA

Reported Saturday, Teva Unveils Data on UZEDY Injection Switching Strategy for Schizophrenia Treatment at ECNP

Teva Pharmaceuticals, a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA), today announced new positive efficacy, safety and tolerability results for Phase 3 Subcutaneous Olanzapine Extended-Release Injection Study (SOLARIS) trial evaluating TEV-‘749 in adult patients diagnosed with schizophrenia. In the study, TEV-‘749 met the primary endpoint, demonstrating significant improvements in the Positive and Negative Syndrome Scale (PANSS)&nbsp;total score from baseline to week 8, as well as key secondary endpoints with improvements in both the Clinical Global Impression-Severity (CGI-S) scale and the Personal and Social Performance (PSP) scale score, compared to placebo at week 8. Additionally, SOLARIS (Period 1) and Phase 1 safety results demonstrated no incidence of post-injection delirium/sedation syndrome (PDSS) in participants taking TEV-‘749 to date.1 The overall safety profile was consistent with other oral acting olanzapine options. These data were presented during the 37th Annual European College of Neuropsychopharmacology (ECNP) Congress taking place between September 21-24, 2024, in Milan, Italy.
Schizophrenia is a complex medical condition that may require switching from oral options or between different long-acting injectable (LAI) options during the patient treatment journey. These data demonstrate the potential role of TEV-‘749 as an LAI treatment option for schizophrenia patients taking daily oral olanzapine or other antipsychotic medications. Currently, the only long-acting olanzapine treatment option for schizophrenia carries a risk for PDSS, the sudden and unexpected onset of delirium or sedation when medication is released too quickly into the blood after receiving an intramuscular injection of long-acting olanzapine.1
"Teva is dedicated to building on its commitment to neuroscience by developing new long-acting injectable treatment options like TEV-‘749 that may help address unmet needs in schizophrenia for patients and healthcare providers," said Eric Hughes, MD, PhD, Executive Vice President of Global R&amp;D and Chief Medical Officer at Teva. "PDSS is a major barrier to the utilization of intramuscular olanzapine LAIs that exists today, and our SOLARIS findings fuel the continued development of TEV-‘749."
With nearly 30 years of clinical and real-world use, olanzapine is one of the most commonly prescribed 2nd generation oral antipsychotics for schizophrenia around the world. Its efficacy and safety profiles are well established.
"Developing a long-acting olanzapine formulation that poses potentially no risk of PDSS is crucial in preventing these dangerous episodes that otherwise limit the use of olanzapine to daily oral options," said Christoph Correll, MD, Professor of Psychiatry at the Zucker School of Medicine, Hempstead, NY. "With no PDSS observed in the SOLARIS trial to date, these data add to the growing body of evidence that TEV-‘749 may one day serve as an important treatment option for patients and healthcare providers who rely on olanzapine and also have needs or preferences that require a long-acting option."
Period 1 of the SOLARIS study is an 8-week, randomized, double-blind, placebo-controlled trial in patients aged 18-64 years diagnosed with schizophrenia, followed by an open-label safety period of up to 48 weeks (Period 2). Efficacy results from Period 1 of the SOLARIS study show that by week 8:
<ul>
<li>TEV-‘749 met its primary endpoint across all three dosing groups, with statistically significant mean differences in the change in PANSS total scores from baseline to week 8 of -9.71 points, -11.25 points, and -9.69 points versus placebo for the high (531 mg, corresponding to 20 mg/day of oral olanzapine), medium (425 mg, corresponding to 15 mg/day of oral olanzapine), and low (318 mg, corresponding to 10 mg/day of oral olanzapine) dose groups, respectively (all P&lt;0.0001).1</li>
<li>TEV-‘749 treatment significantly improved CGI-S scale scores across all three dosing groups, with reductions of -0.47 points (high), -0.61 points (medium), and -0.53 points (low) versus placebo from baseline to week 8 (all P&lt;0.0001).1</li>
<li>TEV-‘749 treatment significantly improved PSP scale scores across all three dosing groups, with increases of 4.93 points (high), 3.15 points (medium), and 4.63 points (low) versus placebo from baseline to week 8 (all P&lt;0.02).1 &nbsp;</li>
</ul>
The systemic safety profile of TEV-‘749 was consistent with other approved formulations of olanzapine, with no new safety signals identified. Additional safety and tolerability results from Period 1 (917 active injections) through week 8 of the SOLARIS study show that:
<ul>
<li>There were no reported cases of PDSS.1</li>
<li>Treatment-emergent adverse events that occurred more often in patients receiving TEV-‘749 versus placebo included weight increase (35% [173/500] versus 8% [13/167]), injection site induration (13% [64/500] versus 2% [4/167]), injection site pain (10% [50/500] versus 4% [7/167]) and injection site erythema (10% [48/500] versus 1% [1/167]).1</li>
<li>Serious adverse events and discontinuations due to adverse events were reported in 1% (7/500) and 3% (16/500) of patients treated with TEV-‘749, respectively, and in 2% (3/167) and 3% (5/167) of patients treated with placebo, respectively.1 &nbsp;</li>
</ul>
Also presented at ECNP 2024, results from the Phase 1 study of TEV-'749 show similar safety and tolerability results, including no reports of PDSS events. Additionally, a presented pre-clinical study suggests that the subcutaneous route of administration and formulation characteristics of TEV-'749 appear to greatly reduce the hypothesized risk of PDSS occurrence for patients receiving the treatment.
The long-term safety of TEV-‘749 and incidence of PDSS are also being evaluated in the SOLARIS open-label study (Period 2), with safety data topline readout expected in the first half of 2025.
TEV-‘749 utilizes SteadyTeq&#x2122;, a copolymer technology proprietary to Medincell that provides a controlled steady release of olanzapine.
TEV-‘749 is an investigational once-monthly subcutaneous LAI of the 2nd generation antipsychotic olanzapine and is not approved by any regulatory authority for any use, and its safety and efficacy are not established.

Reported Saturday, Teva's New Schizophrenia Treatment TEV-749 Meets Key Endpoints in Phase 3 Study

IDEAYA Biosciences, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IDYA#NASDAQ">IDYA</a>), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, today announced that the company plans to issue a pre-market press release and conduct an investor webcast on&nbsp;Monday, September 23, 2024, at 8:00 a.m. ET to report interim Phase 2 data for darovasertib and provide a regulatory update from FDA Type C meeting in neoadjuvant uveal melanoma (UM). Darovasertib is a potent and selective protein kinase C (PKC) inhibitor being developed to broadly address primary and metastatic UM.
&nbsp;
The investor webcast presentation agenda to review the interim Phase 2 clinical data and regulatory update for darovasertib in neoadjuvant UM will be the following:
<ul>
<li>Market introduction: annual incidence of UM</li>
<li>Registrational trial design based on FDA Type C meeting guidance</li>
<li>Phase 2 clinical data update
<ul>
<li>Baseline characteristics</li>
<li>AE profile</li>
<li>Clinical efficacy from Phase 2 company-sponsored and&nbsp;IST</li>
</ul>
</li>
</ul>
The investor webcast and conference call will include participation from a key opinion leader. IDEAYA management, Yujiro S. Hata, Chief Executive Officer and President of IDEAYA Biosciences, and Darrin Beaupre, M.D., Ph.D., Chief Medical Officer of IDEAYA Biosciences, will also serve as presenters. The link to the investor webcast will be available on the&nbsp;<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4260191-1&amp;h=3377453956&amp;u=https%3A%2F%2Fwww.globenewswire.com%2FTracker%3Fdata%3DaZNKgmjyzMiSsMV9B-Z278MGSBmp7QT7selVCYln7cme2BlMujELVbZsAvmEnglHhEEP1UAiAlw0tD0KLcJ62HpJpBtsaRzd339TU33692AfxZb1oqzMHlryeai5G-mo&amp;a=Investor">Investor</a> Relations&nbsp;Events section of the Company's website at: <a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4260191-1&amp;h=1643450813&amp;u=https%3A%2F%2Fir.ideayabio.com%2Fevents&amp;a=https%3A%2F%2Fir.ideayabio.com%2Fevents">https://ir.ideayabio.com/events</a>. Registration is available at <a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4260191-1&amp;h=1643450813&amp;u=https%3A%2F%2Fir.ideayabio.com%2Fevents&amp;a=https%3A%2F%2Fir.ideayabio.com%2Fevents">https://ir.ideayabio.com/events</a> or <a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4260191-1&amp;h=1935289296&amp;u=https%3A%2F%2Flifescievents.com%2Fevent%2Fideaya-3%2F&amp;a=https%3A%2F%2Flifescievents.com%2Fevent%2Fideaya-3%2F">https://lifescievents.com/event/ideaya-3/</a> in advance of the event.

IDYA

Reported Sunday, IDEAYA Biosciences to Announce Interim Phase 2 Data for Darovasertib in Uveal Melanoma

Pedro Azagra, CEO of Avangrid, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/AGR#NYSE">AGR</a>), a leading sustainable energy company and member of the Iberdrola Group, today issued the following statement at the start of Climate Week NYC. "Under the leadership of Iberdrola's Executive Chairman Ignacio Galán, Avangrid has embarked on a journey to purposefully and confidently lead the clean energy transition in the United States. We recognize that we stand at a pivotal moment in our history, as we mark the beginning of Climate Week NYC, where the urgency to fight climate change has never been greater. Every devastating storm, heat wave, or drought – likely made more extreme due to our changing climate – demonstrates the need for immediate action. In keeping with this year's theme, it's time to accelerate progress. With a growing portfolio of over 9 Gigawatts of clean energy installed, and with America's first large-scale offshore wind farm currently under construction, we aren't just promising a greener future, we are building it today. Along the way, we are making record investments in our networks to help our millions of power customers weather the next extreme event fueled by climate change. The demand for safe, clean, affordable electricity to power our homes and businesses will keep growing. Together with our global partners, Avangrid has been at the forefront of the energy transition and will continue forging ahead to achieve our common goal of creating a healthier tomorrow that will ensure the well-being of generations to come."

Government

Regulations

Reported Sunday, Avangrid CEO Pedro Azagra Urges Climate Action, Highlights Clean Energy Progress at Climate Week NYC

While the first day of fall was ushered in across the Gulf Coast region at 7:43&nbsp;a.m. central time Sunday, there are still several more weeks remaining in the 2024 hurricane season. That is why CenterPoint Energy has been closely monitoring weather forecasts in the Gulf of Mexico this weekend and following its standard preparedness protocols. Greater clarity on the weather situation is expected from the National Hurricane Center in the coming days, but CenterPoint and its frontline electric and gas crews remain ready.
<a href="https://mma.prnewswire.com/media/95201/centerpoint_energy_logo.html"><img src="https://mma.prnewswire.com/media/95201/centerpoint_energy_logo.jpg" alt="CenterPoint Energy logo. (PRNewsFoto)" /></a>
In preparation for potential severe weather across the Gulf Coast, CenterPoint will continue to monitor and prepare as the situation evolves. In the event it is needed, the company will begin the process of securing work sites, preparing crews and equipment, and securing additional frontline resources from mutual assistance companies, as necessary. And while autumn days may be on everyone's minds, the company wants to remind customers and the public to develop an emergency plan and assemble or restock a <a href="https://youtu.be/oshsLHzUEOg">storm preparedness kit</a> that includes essential items such as nonperishable food, water, flashlights, batteries, a first aid kit, any necessary medications, a battery-powered radio, and a portable charger for mobile devices.&nbsp;
"It's important to be mindful of the weather and plan ahead," said Darin Carroll, Senior Vice President, Electric Business. "Although schools are back in class and football games highlight our weekends, we have to keep an eye on the Gulf and be prepared to act quickly, if necessary. We want our customers and communities to know that we are constantly monitoring the weather and refining and updating our preparations and plans."
Carroll added, "Since Hurricane Beryl we've made significant improvements to our electric system as part of the Greater Houston Resiliency Initiative. We believe our actions since Beryl will help improve the resiliency and reliability of the electric grid and better meet our customers' expectations."
Greater Houston Resiliency Initiative
Across Greater Houston, CenterPoint is taking action now to improve resiliency and help reduce the risk of outages this hurricane season.&nbsp;
As part of the first phase of its Greater Houston Resiliency Initiative, throughout August CenterPoint crews and contractors installed more than 1,100 stronger and more resilient fiberglass poles, trimmed vegetation along more than 2,000 miles of power lines and installed more than 300 automation devices in neighborhoods all over Houston. The company's next step is taking the boldest series of resiliency actions in its nearly 160-year history, including additional system hardening, strategic undergrounding, self-healing grid technology, and further enhancements to its outage tracker.
Call to Action: Power Alert Service
Customers should remember that a storm is a powerful force of nature that can cause significant damage and widespread lengthy electricity outages. Conditions can also change unexpectedly and for the worse.
Customers are encouraged to enroll in <a href="https://www.centerpointenergy.com/en-us/residential/services/electric-utility/outage-center/power-alert-service?sa=ho&amp;WT.mc_id=VanURL_PAS_On">Power Alert Service&#xAE;</a> to receive outage details, estimated restoration times as available or determined, and customer-specific restoration updates in the event of severe weather. With the option to receive updates via phone call, text or email, Power Alert Service&#xAE; helps keep customers informed of restoration progress during an outage event. Customers can also find additional resources at <a href="https://www.centerpointenergy.com/en-us/residential/safety/weather-storm-center?sa=ho">CenterPointEnergy.com/StormCenter</a>.&nbsp;
New and Improved Outage Tracker with Greater Web Resiliency
CenterPoint's new and improved <a href="http://centerpointenergy.com/OutageTracker#sthash.5KkUvaRI.dpuf">Outage Tracker</a> can be used to update individual customers on their expected restoration date as soon as possible after restoration expectations are determined.&nbsp;
To learn more about Outage Tracker's new features and functionality, watch the demonstration&nbsp;<a href="https://www.youtube.com/watch?v=UY40X8UFq5E">video</a>.
For an in-depth, step-by-step guide to using the Outage Tracker,&nbsp;<a href="https://www.centerpointenergy.com/en-us/Documents/Outage_Tracker_Walkthrough.pdf">click here</a>.&nbsp;&nbsp;
Customers with Critical Needs
Because CenterPoint Energy cannot guarantee an uninterrupted, regular or continuous power supply during a severe weather event, customers who depend on electricity for life-sustaining equipment are encouraged to make alternate arrangements for on-site backup capabilities or other alternatives in the event of loss of electric service.&nbsp;
During pre-storm preparations and post-storm recovery efforts, CenterPoint urges customers to stay informed of weather conditions and warnings or advisories issued by local authorities by paying close attention to announcements from local news outlets for important information regarding ongoing conditions and recovery efforts. The company also recommends that customers follow these important natural gas and electric safety tips:&nbsp;

Reported Sunday, CenterPoint Energy Prepares for Hurricane Season, Urges Customers to Stay Ready

FFIE

Faraday Future Announced It Delivered An FF 91 2.0 Futurist Alliance To Born Leaders Entertainment In The Famous Warwick Club In Hollywood On September 20

IPHA

Innate Pharma Announced That The US FDA Has Cleared Its Investigational New Drug (IND) Application To Initiate A Phase 1 Clinical Study Of IPH4502, A Nectin-4 ADC To Be Developed In Solid Tumors

<a href="https://www.globenewswire.com/Tracker?data=4qPy0caPR_MD2ZH_btFsxurCYUBnsieYZfcpBfbj_y1uh1qAF_Gp0uHf71uFje-4L3liTH4Ck9e75tC9zBDn7w==">Acronis</a>, a global leader in <a href="https://www.globenewswire.com/Tracker?data=yw_TI8F-_ILezlPytFRE3x7pwtcOwSbAb6P3fAZp0PW4T5jIm4Ot8CM5-ZdfNLk56KK8R-hR5aK-S4y0FObRi0y6XZHzWrb40BxPboGLWG23k-IeBkRTj1_RQZk935V6">cybersecurity</a> and <a href="https://www.globenewswire.com/Tracker?data=JBSvRUTEWeaLaIra4D2jWRfL7WaeYd4wWiNah8FbgWQp2KHKab73ky42mDD7yYufYQakvDLErLRJTPw_0kmzN16al293OOuimL589aoY-F73hNDvnUXsRNrsJEks9oRM">data protection</a>, is excited to announce its latest Acronis #TeamUp Partner, FC Bayern Munich Basketball. In partnership with TD SYNNEX Germany, a leading global distributor and aggregator of solutions for the IT ecosystem, the German Basketball champion will leverage Acronis' solutions to uplevel its IT infrastructure and capabilities. &nbsp;
"We are proud to join forces with Bayern Munich and TD SYNNEX," said Markus Fritz, General Manager DACH at Acronis. "At Acronis, our focus is on delivering comprehensive cyber protection solutions. With an emphasis on expanding our presence in Germany, partnering with FC Bayern Basketball, a team renowned for its excellence and achievements, aligns perfectly with our goal to #TeamUp with champions and make a positive impact in the region. This collaboration merges top-tier technology and sports excellence, and we look forward to a successful and impactful partnership."
Bayern Munich is a prominent force in German basketball, with six German championships and five German Cup victories to their name. Most recently, the team secured the national championship for the 2023-2024 season. But FC Bayern Basketball's excellence extends beyond domestic success. Three players from Bayern Munich were key members of the German national team that won the World Cup in 2023, showcasing their talent on the global stage. Plus, three Bayern players represented Germany in the Men's Olympic Basketball Tournament in Paris 2024. These achievements highlight the growing popularity of basketball in Germany and affirm the team's influential role in the sport's development within the country and beyond.
"Partnering with Acronis and TD SYNNEX represents a significant milestone for our club," said Marko Pesic, CEO of FC Bayern Basketball. "This collaboration underscores our commitment to innovation and excellence both on and off the court. We are thrilled to work with two industry leaders in technology to bring together new opportunities that will strengthen our organization."
TD SYNNEX is the exclusive Acronis #CyberFit Partner for the DACH region. As the Acronis #CyberFit Partner for FC Bayern Basketball, TD SYNNEX will leverage Acronis solutions to enhance the basketball team's IT infrastructure. This joint venture will offer a range of benefits, including invitations to high-profile club events and membership in the club's Business Circle. From corporate events to behind-the-scenes tours, this collaboration comes with a wide array of perks for all parties involved.
"At TD SYNNEX, we are committed to empowering organizations through robust IT infrastructure," said Maximilian Wieser, Business Unit Manager Data &amp; Applications der TD SYNNEX. "By providing the tools that drive innovation, we aim to enhance Bayern Basketball's technological capabilities with Acronis solutions. This fuels our mission to empower organizations and supporting the growth of basketball in Germany is an added benefit. Together, we bring a strong foundation for future success."
Service providers are invited to join the Acronis #TeamUp Program to deliver Acronis Cyber Protection solutions to world-class and global professional sports teams.

Acronis Teams Up with FC Bayern Basketball and TD SYNNEX to Boost IT Infrastructure

Reported Earlier, Teva Pharmaceutical Disclosed That A New Analysis Revealed That Deutetrabenazine Treatment Of Patients With Tardive Dyskinesia (TD) Was Associated With Long Term Improvement Of TD Symptoms

It is with regret that Caledonia Mining Corporation Plc ("Caledonia")&nbsp;(NYSE:<a href="https://www.benzinga.com/stock/CMCL#NYSE">CMCL</a>, AIM: CMCL, VFEX: CMCL)))&nbsp;reports that an accident took place on September 21, 2024 at the Blanket Mine in Zimbabwe, where an employee was hit by a fall of rock while drilling in a development area and as a result has sadly died. &nbsp;
Management at Blanket Mine are assisting the relevant authorities in their enquiry into this accident.
Caledonia expresses its condolences to the family and colleagues of the deceased.

CMCL

Caledonia Mining Reports Fatal Accident at Blanket Mine in Zimbabwe

Topline results from the <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT05104866&amp;esheet=54125378&amp;newsitemid=20240921214470&amp;lan=en-US&amp;anchor=TROPION-Breast01&amp;index=1&amp;md5=38bfe55b682fc21bfb63c9c96538d6dd">TROPION-Breast01</a> phase 3 trial of datopotamab deruxtecan (Dato-DXd) compared to investigator's choice of chemotherapy, which previously met the dual primary endpoint of progression-free survival (PFS), did not achieve statistical significance in the final overall survival (OS) analysis in patients with inoperable or metastatic hormone receptor (HR) positive, HER2 low or negative (IHC 0, IHC 1+ or IHC 2+/ISH-) breast cancer previously treated with endocrine-based therapy and at least one systemic therapy.
Datopotamab deruxtecan is a specifically engineered TROP2 directed DXd antibody drug conjugate (ADC) discovered by Daiichi Sankyo (TSE: 4568) and being jointly developed by Daiichi Sankyo and AstraZeneca (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AZN#NASDAQ">AZN</a>).
This analysis follows the positive PFS results <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.daiichisankyo.com%2Ffiles%2Fnews%2Fpressrelease%2Fpdf%2F202310%2F20231023_E2.pdf&amp;esheet=54125378&amp;newsitemid=20240921214470&amp;lan=en-US&amp;anchor=presented&amp;index=2&amp;md5=cff8252e7446c8d69a1c27fc9fce80e2">presented</a> at the 2023 European Society for Medical Oncology Congress which showed datopotamab deruxtecan demonstrated a statistically significant and clinically meaningful improvement in PFS. An improvement in patient-reported outcomes was also seen.1 The PFS data and additional results for key secondary endpoints were published this month in the <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fascopubs.org%2Fdoi%2F10.1200%2FJCO.24.00920&amp;esheet=54125378&amp;newsitemid=20240921214470&amp;lan=en-US&amp;anchor=Journal+of+Clinical+Oncology&amp;index=3&amp;md5=e7ed20db0874315d5367f7b02d51353a">Journal of Clinical Oncology</a>.
The safety profile of datopotamab deruxtecan was consistent with that observed in the previous analysis, including lower rates of grade 3 or higher treatment-related adverse events compared to chemotherapy, and no new safety concerns identified. All grade interstitial lung disease (ILD) rates remained low with no new grade 3 or higher ILD events observed.
With ADCs approved during the course of the trial, including ENHERTU&#xAE; (trastuzumab deruxtecan), subsequent treatment following patients' disease progression or treatment discontinuation is likely to have affected survival results.
"Datopotamab deruxtecan has previously shown a statistically significant progression-free survival benefit in TROPION-Breast01, a result supported by multiple meaningful secondary measures including patient-reported outcomes," said Ken Takeshita, MD, Global Head, R&amp;D, Daiichi Sankyo. "We are proud to have brought forth a new standard of care for patients with metastatic breast cancer with ENHERTU and we remain committed to making datopotamab deruxtecan another potential option for patients who can benefit."
"The metastatic HR positive breast cancer treatment landscape has advanced remarkably in the last several years to the benefit of patients," said Susan Galbraith, MBBChir, PhD, Executive Vice President, Oncology R&amp;D, AstraZeneca. "Based on the TROPION-Breast01 results, there is evidence of the clinical value of datopotamab deruxtecan in this setting. We will continue discussions with regulatory authorities and apply insights from these results to our clinical development program for datopotamab deruxtecan in breast cancer."
The data will be presented at an upcoming medical meeting and shared with regulatory authorities currently reviewing applications for this indication.
In addition to TROPION-Breast01, Daiichi Sankyo and AstraZeneca are evaluating datopotamab deruxtecan alone and with immunotherapy as treatment for patients with triple negative or HR low, HER2 negative breast cancers in the <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT05374512&amp;esheet=54125378&amp;newsitemid=20240921214470&amp;lan=en-US&amp;anchor=TROPION-Breast02&amp;index=4&amp;md5=01feaaff425affd80759eb06d8c92034">TROPION-Breast02</a>, <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.clinicaltrials.gov%2Fstudy%2FNCT05629585&amp;esheet=54125378&amp;newsitemid=20240921214470&amp;lan=en-US&amp;anchor=TROPION-Breast03&amp;index=5&amp;md5=bb5bdbad13d3fdfbaf1635f870880f2a">TROPION-Breast03</a>, <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT06112379&amp;esheet=54125378&amp;newsitemid=20240921214470&amp;lan=en-US&amp;anchor=TROPION-Breast04&amp;index=6&amp;md5=191cffef0ab77f965d8b58af4ebbca39">TROPION-Breast04</a> and <a href="https://cts.businesswire.com/ct/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT06103864&amp;esheet=54125378&amp;newsitemid=20240921214470&amp;lan=en-US&amp;anchor=TROPION-Breast05&amp;index=7&amp;md5=0f12d2808ec2428fa29d6d8aabb36d6e">TROPION-Breast05</a> phase 3 trials.

Daiichi Sankyo and AstraZeneca's Datopotamab Deruxtecan Falls Short on Survival in Breast Cancer Trial

This story was originally published on the&nbsp;<a href="http://in.benzinga.com/" target="_blank">Benzinga India portal</a>.
The Competition Commission of India (CCI) has reportedly intensified its antitrust investigation into e-commerce giants&nbsp;Amazon (NASDAQ: <a class="ticker" href="https://www.benzinga.com/stock/amzn#NASDAQ">AMZN</a>)&nbsp;and&nbsp;Walmart (NYSE: <a class="ticker" href="https://www.benzinga.com/stock/wmt#NYSE">WMT</a>)-backed&nbsp;Flipkart, requesting their financial statements.
What Happened: The CCI&#39;s demand for financial records from Amazon Seller Services and Flipkart Internet will play a major role in determining a potential penalty on the firms, based on the companies&#39; defense in a four-year-long case, Mint reported.
A 2023 amendment to the competition law enables the CCI to impose a fine of up to 10% of a company&#39;s global turnover or income of the preceding three financial years for anti-competitive conduct.
The global turnover is anticipated to encompass the revenue generated by the entity in India and overseas, excluding the turnover of any sister enterprise operating in a different market.&nbsp;
After CCI&rsquo;s Director General of Investigation (DG) findings were reported in the media, Amazon and Flipkart raised concerns about the potential public disclosure of sensitive information in non-confidential reports.
Do you want to keep up with all the latest stock market updates in India? Sign up for the&nbsp;<a href="https://share.hsforms.com/1K1H7Kd0aRhmSdDIuxTAkxg1npzh?utm_source=hs_email&amp;utm_medium=email&amp;_hsenc=p2ANqtz-9Epn7q6aJNp9GSC5EOIhi4bHzDb9Xseqz4PYaEI7sGMhIcV2Rv9ZPxiCYKVKvNojA6WoH5" target="_blank">Benzinga India weekly newsletter</a>.
The DG&#39;s findings, which will serve as the foundation for CCI&rsquo;s judgment on the case, examined complaints of alleged anti-competitive behavior by the two e-commerce giants. The companies will have the chance to defend their case once the confidential version of the report is shared with them.
This comes after the DG&#39;s confirmation in August of suspected violations of competition law by the two internet platforms. Practices under scrutiny include giving preferential treatment and preferential listing to certain sellers on the platform, exclusive product launches and deep discounting, which may have adversely affected small retailers on the platform and beyond.
Read Next:&nbsp;<a href="https://in.benzinga.com/news/24/09/40970969/indian-coldplay-fans-cry-foul-as-tickets-hit-2-lakh-on-reselling-platform">Indian Coldplay Fans Cry Foul As Tickets Hit Sky-High Prices&nbsp;On Reselling Platform</a>
Disclaimer: Artificial intelligence was used as a secondary aid in writing this story.

Global

Markets

Tech

AMZN

India's Competition Watchdog Seeks Financial Records From Amazon, Walmart-Backed Flipkart In Ongoing Antitrust Probe: Report

Unifor members at General Motors&#8216; (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GM#NYSE">GM</a>) CAMI Assembly and Battery Assembly plants in Ingersoll, Ontario, have ratified a <a href="https://www.benzinga.com/news/24/09/40915192/canadian-union-unifor-reaches-agreement-with-general-motors-for-over-1-300-workers-in-ontario">new collective agreement </a>with the automaker, the Canadian union said on Sunday.
What Happened: The new two-year contract provides a 15% wage increase for production workers and a 20.25% pay hike for skilled trades through the end of its term. 
The union said that Unifor Local 88, representing over 1,300 workers at CAMI Assembly and Battery Assembly, voted 95.7% in favor of ratifying the new agreement. The contract is now set to expire on September 20, 2026.
"CAMI workers have been trailblazers in the EV transition and our bargaining committee was determined to bring home the wage increases, pension improvements and income replacement measures to protect them during this evolution and position them for the future," Unifor CAMI Plant Chairperson Mike Van Boekel said. 
Why It Matters: The CAMI Assembly plant workers build the&nbsp;<a href="https://www.benzinga.com/news/24/08/40646381/gm-to-move-brightdrop-electric-vans-under-the-chevrolet-brand" target="_blank" rel="noreferrer noopener">Chevrolet BrightDrop EV 600 and EV 400</a>&nbsp;while the battery assembly facility workers assemble the company's Ultium battery modules.
The new contract, Unifor said, also provides for improved income security provisions to protect workers during the transition from gas-powered to electric vehicles. 
GM did not immediately respond to Benzinga&#8216;s request for comment. 
Check out more of Benzinga's Future Of Mobility coverage by&nbsp;<a href="https://www.benzinga.com/topic/mobility" target="_blank" rel="noreferrer noopener">following this link</a>.
Read Next:
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<li><a href="https://www.benzinga.com/news/24/09/40913617/embraer-controlled-eve-air-mobility-ropes-in-former-rolls-royce-exec-as-chief-commercial-officer" target="_blank" rel="noreferrer noopener">Embraer-Controlled Eve Air Mobility Ropes In Former Rolls-Royce Exec As Chief Commercial Officer</a></li>
</ul>
Image via shutterstock

General

Unifor Members At GM's CAMI Assembly And Battery Assemble Plants Secure New Contract With Pay Increases

Arthur Hayes, the co-founder of cryptocurrency exchange BitMEX, signaled interest in Australian rapper Iggy Azalea's memecoin Mother Iggy (MOTHER), owing to favorable macroeconomic conditions.
What happened: In an X post late Sunday night, Hayes highlighted how Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) remained stable over the weekend as the Japanese Yen weakened following the Bank of Japan's decision to keep its <a href="https://www.benzinga.com/markets/asia/24/09/40951221/bank-of-japan-leaves-interest-rate-at-0-25-diverging-from-feds-50-basis-point-cut">benchmark interest rates unchanged</a>.
Since the announcement, the yen indeed fell from 142.50 to 144.18 as of this writing, while Bitcoin made steady advances.&nbsp;
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">.<a href="https://twitter.com/IGGYAZALEA?ref_src=twsrc%5Etfw">@IGGYAZALEA</a> can you be my <a href="https://twitter.com/search?q=%24MOTHER&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$MOTHER</a>? I was wrong <a href="https://twitter.com/search?q=%24JPY&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$JPY</a> weakening, <a href="https://twitter.com/search?q=%24BTC&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$BTC</a> held up well over the weekend. LFG, and let the good times roll. Time to trade some dogshit meme coins.
&mdash; Arthur Hayes (@CryptoHayes) <a href="https://twitter.com/CryptoHayes/status/1838067229151412572?ref_src=twsrc%5Etfw">September 23, 2024</a></blockquote>
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Hayes viewed this as an opportunity to trade &#8216;s&#x2A;&#x2A;tcoins&#8217; and made a cheeky reference to the popular rapper&#8217;s memecoin, asking, &#8220;Iggy Azalea, can you be my $MOTHER?
Hayes, one of the keen observers of the cryptocurrency market and the U.S. macroeconomy, holds about $28.63 million in digital assets, <a href="https://platform.arkhamintelligence.com/explorer/entity/arthur-hayes">according </a>to Arkham Intelligence. 
See Also: <a href="https://www.benzinga.com/markets/cryptocurrency/24/09/40950912/bitcoins-reserve-asset-appeal-increased-due-to-state-of-us-federal-deficit-and-debt-says-b">Bitcoin&#8217;s Reserve Asset Appeal Increased Due To State Of US Federal Deficit And Debt, Says BlackRock: A Hedge Against &#8216;Possible Future Events&#8217; Affecting The Dollar</a>
Why It Matters: Since <a href="https://www.benzinga.com/markets/cryptocurrency/24/06/39222886/meme-dream-come-true-investor-turns-777k-into-9-4m-in-just-8-days-betting-on-iggy-azaleas-">its launch in June</a>, the Solana (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/sol/usd">SOL</a>)-based memecoin has grown by a whopping 280%, amassing a market cap of more than $73 million.
While concerns about celebrity-promoted cryptocurrencies and their short-lived hype have run rife, Azalea's token has found purpose in real-world applications.
Last week, the Grammy-nominated artist announced plans to launch an online casino called Motherland, which would utilize the MOTHER token.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">With love &#8211; you are wrong. Iam not building a simple "casino" online as we understand them to be now and a little research on my page &amp; telegram before typing this would've helped you understand better. I've seen many outlets reporting it in a lazy way framed simply as "a… <a href="https://t.co/4IYnJrsHYg">https://t.co/4IYnJrsHYg</a>
&mdash; IGGY AZALEA (@IGGYAZALEA) <a href="https://twitter.com/IGGYAZALEA/status/1837511000574378449?ref_src=twsrc%5Etfw">September 21, 2024</a></blockquote>
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Price Action: At the time of writing, MOTHER was exchanging hands at $0.0747, up 3.50% in the last 24 hours, according to data from CoinMarketCap.
Photo by Fernando Cortes on Shutterstock
Read Next:&nbsp;
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<li><a href="https://www.benzinga.com/markets/cryptocurrency/24/09/40972902/kamala-harris-finally-mentions-crypto-and-that-too-on-wall-street-promises-to-encourage-in">Kamala Harris Finally Mentions Crypto And That Too On Wall Street: Promises To Encourage &#8216;Innovative Technologies&#8217; Like Digital Assets</a></li>
</ul>

Coverage of Bitcoin, Etherum, Ripple and all the latest digital currencies.

Cryptocurrency

Entertainment

$BTC

$SOL

Bitcoin Bull Arthur Hayes Planning To Buy Iggy Azalea's MOTHER token?

Ahead of the November election, Vice President Kamala Harris is set to introduce new economic policies aimed at wealth creation this week.
What Happened: The proposals, expected to be announced midweek in Pittsburgh, come as undecided voters seek more clarity on Harris&#8217; economic plans ahead of the November election. The new policies aim to help Americans build wealth and provide economic incentives for businesses, Reuters reported on Monday, citing three sources with knowledge of the matter.
Harris stated that her plan focuses on investing in the aspirations and ambitions of the American people while addressing their economic challenges. The rollout follows internal debates within the Democratic Party about the timing of releasing new economic policies so close to election day.
According to the report, Harris aims to show voters a path to building wealth, emphasizing affordability and economic opportunities. Specific details of the new policies remain undisclosed, and the Harris campaign has not commented on the proposals.
Harris&#8217; previous economic plans have included significant pay hikes for public school teachers, addressing pay gaps, and eliminating bias in home appraisals. Her new proposals are expected to build on these initiatives and align with President Joe Biden&#8216;s policies.
&#8220;It&#8217;s not just about affordability, it&#8217;s also about showing (voters) they have a path to building wealth,&#8221; said a person with direct knowledge of Harris&#8217;s economic plans, according to the report. 
See Also: <a href="https://www.benzinga.com/news/earnings/24/09/40954521/wall-street-looks-to-pause-after-s-ps-record-performance-as-fed-rate-cut-euphoria-fades-and-hard-la?itm_source=parsely-api" target="_blank" rel="noreferrer noopener">S&amp;P 500 Futures Slip As Fed Cut Euphoria Fades: What&#8217;s Going On</a>
Campaign spokesman James Singer mentioned that Harris will continue to present her economic agenda to lower costs, make housing more affordable, and spur economic growth across America, according to the report.
Why It Matters: The announcement of new economic policies by Harris comes at a pivotal moment in her campaign. 
The polls suggest a slight <a href="https://www.benzinga.com/news/24/09/40969584/trump-vs-harris-this-candidate-has-the-edge-in-latest-swing-state-polls">advantage for Harris over Trump</a>. A Morning Consult poll shows Harris leading by 6 percentage points nationwide, her largest lead in the organization's surveys to date.
The race remains tight, with high-profile endorsements playing a crucial role. Harris recently received her second endorsement in 179 years from the <a href="https://www.benzinga.com/general/politics/24/09/40907893/kamala-harris-wins-second-endorsement-in-179-years-from-magazine-that-featured-works-from-nikola" target="_blank" rel="noreferrer noopener">oldest continuously published magazine in the U.S.</a>, which has featured works from luminaries like Nikola Tesla and Albert Einstein.
Additionally, Harris has faced criticism from notable figures like Bill Ackman, who questioned her candidacy and the circumstances surrounding her rise. In response, billionaire Mark Cuban defended Harris, <a href="https://www.benzinga.com/news/24/09/40972809/mark-cuban-issues-a-stinging-retort-to-bill-ackmans-attack-on-kamala-harris-she-is-kicking-your-a">emphasizing her effectiveness and leadership</a>.
Furthermore, former President Donald Trump has stated that he will not pursue another presidential run if he loses to Harris in the upcoming election. This declaration adds another layer of significance to Harris&#8217; economic proposals, as they could <a href="https://www.benzinga.com/news/24/09/40972774/trump-says-no-to-another-run-if-he-loses-2024-election-to-kamala-harris-hopefully-were-going-to-be-s">potentially sway undecided voters</a>.
Read Next: <a href="https://www.benzinga.com/news/24/09/40969744/mark-cuban-embraces-elon-musks-humor-i-have-no-problem-throwing-elon-under-the-bus-but-ill-save-it-f">Mark Cuban Embraces Elon Musk&#8217;s Humor: &#8216;I Have No Problem Throwing Elon Under The Bus, But I&#8217;ll Save It For When It&#8217;s Truly Deserved&#8217;</a>
Image via Wikimedia Commons
This story was generated using <a href="https://www.benzinga.com/author/benzinga-neuro">Benzinga Neuro</a> and edited by <a href="https://www.benzinga.com/topic/Kaustubh-Bagalkote" target="_blank" rel="noreferrer noopener">Kaustubh Bagalkote</a>

Economics

Kamala Harris Reportedly Set To Unveil New Economic Policies In Pittsburgh This Week: Its About Showing Voters They Have A Path To 'Building Wealth'

Apollo Global Management Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/APO#NYSE">APO</a>) has reportedly been considering a multibillion-dollar investment in Intel Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INTC#NASDAQ">INTC</a>).
What Happened: Apollo has proposed to make an equity-like investment of up to $5 billion in Intel, <a href="https://www.bloomberg.com/news/articles/2024-09-22/apollo-is-said-to-offer-multibillion-dollar-investment-in-intel?srnd=phx-technology">reported</a> Bloomberg, citing people familiar with the matter.
As per the sources, Intel&#8217;s executives are currently evaluating Apollo&#8217;s proposal.&nbsp;
The size of the investment could change and there are also some chances that the discussions could fall through.
See Also: <a href="https://www.benzinga.com/markets/equities/24/09/40949356/mobileye-soars-after-intel-says-it-will-not-sell-majority-stake">Mobileye Soars After Intel Says It Will Not Sell Majority Stake</a>
Apollo and Intel already have a business relationship.
Earlier this year in June, Intel agreed to sell a stake in a joint venture controlling a plant in Ireland to Apollo for $11 billion.
Why It Matters: This development occurred after it was reported that Qualcomm Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QCOM#NASDAQ">QCOM</a>) was <a href="https://www.benzinga.com/news/24/09/40968128/qualcomm-reportedly-eyes-potential-takeover-of-intel-amid-60-stock-decline-but-antitrust-concerns-lo">planning to acquire Intel</a>.
If the Qualcomm-Intel deal goes through, it could result in one of the largest M&amp;A deals ever, surpassing Microsoft Corporation's <a href="https://www.benzinga.com/general/gaming/23/10/35240972/microsofts-gaming-powerhouse-grows-activision-blizzard-bought-for-69-billion">$69 billion acquisition</a> of Activision Blizzard.
Intel's <a href="https://www.benzinga.com/news/earnings/24/08/40115276/intel-stock-falls-after-weak-q2-results-new-cost-reduction-plan-15-headcount-reduction">second-quarter earnings</a> reflected an 84.62% decline from the same period last year. The company reported quarterly earnings of 2 cents per share, which fell significantly short of the analyst consensus estimate of 10 cents.
In August it was reported that a prominent board member at Intel, Lip-Bu Tan resigned from his position following a dispute with CEO Pat Gelsinger and other directors.
This raised concerns about the company's direction.
Read Next:
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<li><a href="https://www.benzinga.com/insights/options/24/09/40924119/looking-at-intels-recent-unusual-options-activity">Looking At Intel&#8217;s Recent Unusual Options Activity</a></li>
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Equities

Media

INTC

QCOM

Intel Has A New Knight In Shining Armor? After Qualcomm, Apollo Global Management Reportedly Proposes Multibillion-Dollar Investment

Anthony Scaramucci, CEO of investment firm&nbsp;SkyBridge Capital and a vocal cryptocurrency advocate, predicted a significant role for Solana (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/sol/usd">SOL</a>) in the impending layer-1 blockchain revolution, while also revealing his substantial exposure to the fifth-largest cryptocurrency.
What Happened: During the recent Breakpoint 2024 conference, Scaramucci highlighted the potential of tokenization to revolutionize the current financial system. He pointed out that approximately $7 trillion is spent annually on transaction verification, a cost that could be significantly reduced through tokenization.
He stressed on the need for eliminating third parties and utilizing blockchain&#8217;s trustless technology to verify transactions.
&#8220;This system is actually a flawless and a near perfect system, and hopefully the tokenization will happen on Solana,&#8221; Scaramucci stated. The former White House Communications Director added that he owns &#8220;a lot of&#8221; Solana.
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">$7 TRILLION a year is spent on transaction verification &#8211; tokenization solves that. The future is tokenized and <a href="https://twitter.com/solana?ref_src=twsrc%5Etfw">@Solana</a> will be a major player in the layer-1 blockchain financial revolution. Enjoyed my not-so-heated debate with <a href="https://twitter.com/FTI_DA?ref_src=twsrc%5Etfw">@FTI_DA</a>&#39;s Christopher Jensen at Breakpoint 2024. <a href="https://t.co/E8EH2aQEbB">pic.twitter.com/E8EH2aQEbB</a>
&mdash; Anthony Scaramucci (@Scaramucci) <a href="https://twitter.com/Scaramucci/status/1837536131350499633?ref_src=twsrc%5Etfw">September 21, 2024</a></blockquote>
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See Also: <a href="https://www.benzinga.com/markets/cryptocurrency/24/09/40971599/well-its-crypto-its-ai-its-some-of-the-other-things-says-donald-trump-unsure-of-what-his-n?itm_source=parsely-api" target="_blank" rel="noreferrer noopener">&#8216;Well, It&#8217;s Crypto, It&#8217;s AI, It&#8217;s Some Of The Other Things,&#8217; Says Donald Trump, Unsure Of What His New Crypto Project Even Is</a>
Why It Matters: Solana is often dubbed as an &#8220;Ethereum Killer&#8221; and its proponents favorably compare the network with Ethereum (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/eth/usd">ETH</a>) on parameters such as transaction speed and cost.
Tokenization of real-world assets was emerging as a hot new narrative in the Web3 realm, with the industry having $5.72 billion in total locked as of this writing, <a href="https://defillama.com/protocols/RWA" target="_blank" rel="noreferrer noopener">according </a>to DeFiLlama.
In layman&#8217;s terms, tokenization can be defined as the process of bringing off-chain assets like bonds, real estate, commodities, and much more on blockchain rails,&nbsp; opening up new avenues of growth for both traditional and decentralized finance.
Price Action: At the time of writing, SOL was exchanging hands at $148.87, up 0.21% in the last 24 hours, according to <a href="https://pro.benzinga.com/dashboard?_gl=1&#x2A;380nj0&#x2A;_ga&#x2A;MTEyOTAyOTcxMy4xNzEzMzY0NTYy&#x2A;_ga_V7ZK73W7N0&#x2A;MTcxNDk4MzIzMi42LjEuMTcxNDk4OTE0Ni4wLjAuMA..">data from Benzinga Pro</a>.
Photo by World Economic Forum on Flickr
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<li><a href="https://www.benzinga.com/markets/cryptocurrency/24/09/40963556/experts-predict-bitcoin-surge-to-65-000-as-crypto-market-remains-steady">Experts Predict Bitcoin Surge To $65,000 As Crypto Market Remains Steady</a></li>
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Disclaimer:&nbsp;This content was partially produced with the help of&nbsp;<a href="https://www.benzinga.com/author/benzinga-neuro" target="_blank" rel="noreferrer noopener">Benzinga Neuro</a>&nbsp;and was reviewed and published by Benzinga editors.

$ETH

Anthony Scaramucci Discloses Holding 'A Lot Of' Solana, Backs The 'Ethereum Killer' Network To Lead Tokenization Revolution

A two-and-a-half-year-old Siamese cat named Rayne Beau was reunited with his owners, Susanne and Benny Anguiano, after disappearing in Yellowstone National Park. The cat lost in the national park traveled over 900 miles to return home after two months.
What Happened: The Anguianos, from Salinas, California, were visiting the park in Wyoming when Rayne Beau wandered off on Jun. 4. Despite daily searches by Benny, the cat could not be found, and the couple had to leave without him.
Two months later, the couple received a notification that Beau had been found in Roseville, California, approximately 190 miles from their home. The cat was identified through his microchip and taken to the Placer Society for the Prevention of Cruelty to Animals.
Leilani Fratis, CEO of the Placer SPCA, confirmed the cat&#8217;s identity and emphasized the importance of microchipping pets. Rayne Beau was initially in poor health but is now back home with his grateful owners.
Susanne Anguiano expressed her joy, saying, &#8220;We are ecstatic to have him back. I look at him every day and am so grateful.&#8221;
See Also: <a href="https://www.benzinga.com/news/24/09/40950674/data-scientist-who-called-2020-election-correctly-says-its-gone-from-drastic-landslide-in-trumps-dir?itm_source=parsely-api" target="_blank" rel="noreferrer noopener">Data Scientist Who Called 2020 Election Correctly Says Its Gone From &#8216;Drastic Landslide In Trump&#8217;s Direction To A Drastic Landslide For Harris&#8217;</a>
Why It Matters: The reunion of Rayne Beau with his owners highlights the significance of microchipping pets, a point emphasized by Leilani Fratis of the Placer SPCA. 
This incident also brings to light the diverse range of events occurring in Yellowstone National Park. For instance, in June 2022, a tourist was gored by a bison after getting too <a href="https://www.benzinga.com/news/22/06/27506856/a-woman-got-too-close-to-a-bison-at-yellowstone-what-do-you-think-happened-to-her">close to the animal</a>, underscoring the need for visitors to adhere to park regulations.
Additionally, the story of Rayne Beau&#8217;s journey comes at a time when <a href="https://www.benzinga.com/news/24/09/40937559/jd-vances-unverified-rumors-about-haitian-immigrants-stir-gop-discomfort-distracting-from-real-issue">pet-related news is gaining attention</a> in the political arena. Recently, Sen. JD Vance (R-Ohio) and former President Donald Trump have made unverified claims about immigrants abducting and eating pets, which have been widely debunked. 
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<li><a href="https://www.benzinga.com/24/09/40954613/kim-jong-uns-show-of-force-with-missiles-indicates-north-korea-is-no-longer-interested-in-negotiatio?itm_source=parsely-api" target="_blank" rel="noreferrer noopener">Kim Jong Un&#8217;s &#8216;Show Of Force&#8217; With Missiles Indicates North Korea Is No Longer Interested In Negotiations With US, Say Analysts</a></li>
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This story was generated using <a href="https://www.benzinga.com/author/benzinga-neuro">Benzinga Neuro</a> and edited by <a href="https://www.benzinga.com/topic/Kaustubh-Bagalkote" target="_blank" rel="noreferrer noopener">Kaustubh Bagalkote</a>

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Apple design legend&nbsp;Sir Jony Ive has confirmed his collaboration with&nbsp;OpenAI&nbsp;CEO&nbsp;Sam Altman, on a new <a href="https://www.benzinga.com/news/23/09/34966565/iphone-of-ai-openais-sam-altman-apple-design-legend-jony-ive-and-softbanks-masayoshi-son-explore-a-n">AI hardware project</a>.
What Happened: Ive confirmed his involvement in the project during a profile <a href="https://www.nytimes.com/2024/09/21/technology/jony-ive-apple-lovefrom.html">interview</a> with The New York Times that was published on Saturday, <a href="https://www.theverge.com/2024/9/21/24250867/jony-ive-confirms-collaboration-openai-hardware">reported</a> The Verge.
The project, which was first rumored nearly a year ago, is still shrouded in mystery with few details available. As per the report, Ive met Altman through Airbnb CEO Brian Chesky.
Funding for the venture is being provided&nbsp;by Ive and the Emerson&nbsp;Collective, a company owned by Laurene Powell Jobs. The project is expected to&nbsp;<a href="https://www.benzinga.com/news/24/04/38130224/sam-altman-and-former-apple-design-maestro-seek-funding-from-laurene-powell-jobs-masayoshi-son-for-t">raise $1 billion in funding&nbsp;by year-end</a>.
See Also:&nbsp;<a href="https://www.benzinga.com/news/24/09/40970948/elon-musk-and-nvidia-ceo-share-vision-of-ai-powered-personal-assistants-linkedin-under-scrutiny-and?itm_source=parsely-api" target="_blank" rel="noreferrer noopener">Elon Musk And Nvidia CEO Share Vision Of AI-Powered Personal Assistants, LinkedIn Under Scrutiny And More: This Week In AI</a>
The team, currently consisting of 10 employees, <a href="https://www.benzinga.com/news/23/12/36393129/apple-iphone-design-executive-joins-forces-with-jony-ive-and-sam-altman-for-groundbreaking-ai-projec">includes key figures</a> like Tang Tan and Evans Hankey who previously&nbsp;worked with Ive on the&nbsp;iPhone.
The project is being led by LoveFrom, Ive&#8217;s company, and is based in&nbsp;a 32,000-square-foot office building in&nbsp;San Francisco.
According to The Times, the device will leverage generative AI to handle complex requests, offering more to users than traditional software. However, specifics about the AI product and its market launch are still being determined.
Subscribe to the&nbsp;<a href="https://bztechtrends.beehiiv.com/subscribe" target="_blank" rel="noreferrer noopener">Benzinga Tech Trends newsletter</a>&nbsp;to get all the latest tech developments delivered to your inbox.
Why It Matters: Previously, it was reported that Altman and Ive intend to develop a more intuitive and seamless way for users to engage with AI. Their goal is to create a transformative experience akin to the impact the original iPhone had on the smartphone industry.
When Apple introduced the first iPhone in 2007, it revolutionized the market, which had been dominated by bulky phones with physical keyboards, by offering a touchscreen-only interface.
In a similar vein, current AI interactions still require manual input, whether through text prompts or voice commands.
Photo courtesy: Wikimedia
Check out more of Benzinga's Consumer Tech coverage by&nbsp;<a href="https://www.benzinga.com/topic/consumer-tech" target="_blank" rel="noreferrer noopener">following this link</a>.
Read Next:
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Disclaimer: This content was partially produced with the help of&nbsp;<a href="https://www.benzinga.com/author/benzinga-neuro" target="_blank" rel="noreferrer noopener">Benzinga Neuro</a>&nbsp;and was reviewed and published by Benzinga editors.

Apple's Former Design Maestro Jony Ive Confirms He's Joined Forces With OpenAI's Sam Altman For A New AI Hardware Project

Popular dog-themed memecoin Shiba Inu (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/shib/usd">SHIB</a>) recorded a significant jump in its burn rate in the last 24 hours, although the community remained unimpressed.
What happened: About 15.08 million SHIB tokens were kicked out of circulation, according to the official burn tracker, <a href="https://www.shibburn.com/">Shibburn</a>, marking a surge of 772% over the last 24 hours.
As is well known, coin burning is the process of purposely sending a cryptocurrency token to an unusable wallet address to remove it from circulation. This is done to generate scarcity and increase the market value of the token.
As of this writing, nearly 410.728 trillion SHIB tokens have gone up in smoke.
Despite the substantial increase in burn rate, many members of the Shiba Inu community were dissatisfied and vented their frustrations to none other than the ecosystem&#8217;s pseudonymous leader, Shytoshi Kusama.
While responding to an altogether different X post by Kusama, a user urged them to accelerate the burn rate.&nbsp;To this, Kusama replied, "Requires funds to do so. Every time you see a partnership, we get closer."
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Requires funds to do so. Every time you see a partnership, we get closer.
&mdash; Shytoshi Kusama&#x2122; (@ShytoshiKusama) <a href="https://twitter.com/ShytoshiKusama/status/1837820942002577920?ref_src=twsrc%5Etfw">September 22, 2024</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
However, the user was still not convinced and went on to say, &#8220;What about that auto-burn mechanism ?! We wait till 4 years. It&#8217;s in YOUR hands ! Dont fool us boss.&#8221;
See Also: <a href="https://www.benzinga.com/markets/cryptocurrency/24/09/40950912/bitcoins-reserve-asset-appeal-increased-due-to-state-of-us-federal-deficit-and-debt-says-b">Bitcoin&#8217;s Reserve Asset Appeal Increased Due To State Of US Federal Deficit And Debt, Says BlackRock: A Hedge Against &#8216;Possible Future Events&#8217; Affecting The Dollar</a>
Why It Matters: The debate around burn rates came even as the highly anticipated liquid staking platform, K9 Finance, <a href="https://www.benzinga.com/markets/cryptocurrency/24/09/40913080/shiba-inu-team-says-launching-k9-finance-liquid-staking-on-shibarium-tomorrow-are-shib-bur">went live</a> on Shiba Inu's Layer-2 network, Shibarium.&nbsp;
The launch was expected to boost transaction volume on the network, in turn accelerating SHIB token burns.&nbsp;
Since its launch in August last year, the Shibarium blockchain has facilitated over 418 million transactions, according to <a href="https://www.shibariumscan.io/stats">on-chain</a> data.
Price Action: At the time of writing, SHIB was exchanging hands at $0.00001479, up 0.22% in the last 24 hours, according to <a href="https://pro.benzinga.com/dashboard?_gl=1&#x2A;380nj0&#x2A;_ga&#x2A;MTEyOTAyOTcxMy4xNzEzMzY0NTYy&#x2A;_ga_V7ZK73W7N0&#x2A;MTcxNDk4MzIzMi42LjEuMTcxNDk4OTE0Ni4wLjAuMA..">data from Benzinga Pro</a>.&nbsp;
Read Next:&nbsp;
<ul>
<li><a href="https://www.benzinga.com/markets/cryptocurrency/24/09/40972902/kamala-harris-finally-mentions-crypto-and-that-too-on-wall-street-promises-to-encourage-in">Kamala Harris Finally Mentions Crypto And That Too On Wall Street: Promises To Encourage &#8216;Innovative Technologies&#8217; Like Digital Assets</a></li>
</ul>

$SHIB

'Dogecoin Killer' Shiba Inu's Burn Rate Shoots Up 772%, Shytoshi Kusama On Picking Up The Pace: 'Requires Funds To Do So'

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