Kadmon Presents Data on New ROCK Inhibitor Clinical Candidate at Anti-Fibrotic Drug Development Summit

NEW YORK, Nov. 29, 2018 (GLOBE NEWSWIRE) -- Kadmon Holdings, Inc. KDMN today announced the presentation of preclinical data supporting the therapeutic potential of Rho-associated coiled-coil kinase (ROCK) inhibition for the treatment of fibrotic diseases. The data will be presented today by Masha Poyurovsky, Ph.D., Vice President of Molecular Signaling at Kadmon, at the 2^nd Annual Anti-Fibrotic Drug Development Summit in Cambridge, MA.  

Kadmon ROCK Inhibitor Platform in Fibrosis
Research conducted by Kadmon and others has identified ROCK as an integral component in the pathogenesis of fibrosis. ROCK regulates pro-fibrotic gene transcription, collagen deposition and fibroblast to myofibroblast differentiation, a defining feature of fibrosis. Kadmon has developed a portfolio of ROCK inhibitors in preclinical discovery for the treatment of fibrotic diseases. Its lead candidate from this program, KD045, has been shown to attenuate fibrosis and stabilize barrier function in various in vivo settings, including in models of renal, hepatic and pulmonary fibrosis. Kadmon plans to submit an Investigational New Drug (IND) application for KD045 in the second half of 2019.  

About Kadmon Holdings, Inc.

Kadmon Holdings, Inc. is a fully integrated biopharmaceutical company developing innovative product candidates for significant unmet medical needs. Our product pipeline is focused on inflammatory and fibrotic diseases.

Forward Looking Statements

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Contact Information
Ellen Cavaleri, Investor Relations
646.490.2989
ellen.cavaleri@kadmon.com