Amgen Announces New Analyses Presented At #ASH2015 Demonstrate Potential Of Kyprolis As Backbone Therapy In Multiple Myeloma

Amgen

today announced the presentation of new key data evaluating Kyprolis® (carfilzomib) -based regimens in patients with relapsed multiple myeloma. The data showed Kyprolis in combination with dexamethasone significantly extended disease progression compared to bortezomib plus dexamethasone across a range of difficult-to-treat populations, specifically those with high risk and previously treated disease. The analyses were presented during the 57th Annual Meeting and Exposition of the American Society of Hematology (ASH) in Orlando, Fla.  Data analyzed in three presentations across patient subgroups from the Phase 3 ENDEAVOR trial showed that patients with relapsed or refractory multiple myeloma, who were treated with Kyprolis plus dexamethasone, achieved superior progression-free survival (PFS) compared to those receiving bortezomib plus dexamethasone. The subgroup analyses evaluated the Kyprolis combination based on prior treatment, cytogenetic risk status and age, respectively (ASH abstracts #729, #30 and #1844). Pivotal data from the Phase 3 ENDEAVOR trial were previously presented at the 2015 Annual Meeting of the American Society of Clinical Oncology (ASCO) and published online in The Lancet Oncology today.  A separate presentation analyzed the efficacy and safety of