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Atmel Corporation (NASDAQ: ATML) shares rose 18.57 percent to $8.62 in pre-market trading after Dialog Semiconductor Plc (OTC: DLGNF) announced its plans to acquire Atmel for around $4.6 billion.

Uniqure NV (NASDAQ: QURE) shares climbed 13.80 percent to $38.02 in pre-market trading following Saturday announcement of positive topline results from Phase I/II trial in Sanfilippo B syndrome patients using AAV5-based gene therapy.

AcelRx Pharmaceuticals Inc (NASDAQ: ACRX) shares rose 9.57 percent to $4.35 in pre-market trading after PDL BioPharma Inc (NASDAQ: PDLI) announced the acquisition of portion of AcelRx Pharma's expected royalties and milestones from Zalviso for $65 million.

Allot Communications Ltd (NASDAQ: ALLT) gained 7.14 percent to $5.25 in pre-market trading after the company reported that it has received an $8 million expansion order from a tier-1 operator.

Shire PLC (ADR) (NASDAQ: SHPG) shares jumped 3.93 percent to $227.09 in pre-market trading following announcement of EC approval of non-stimulant ADHD treatment.

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