Evoke Pharma Announces EVK-001 Phase 2b Results Will be Presented at Digestive Disease Week 2014

Evoke Pharma, Inc.

, a specialty pharmaceutical company focused on treatments for gastrointestinal (GI) diseases, today announced that data from the Company's Phase 2b clinical trial of EVK-001, a novel intranasal formulation and delivery method of metoclopramide for diabetic female patients with symptoms associated with gastroparesis, was accepted for an oral presentation at Digestive Disease Week 2014 (DDW). DDW will take place May 3-6, 2014 in Chicago, Illinois. The multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging Phase 2b study evaluated the efficacy and safety of metoclopramide nasal spray in patients with symptoms associated with acute and recurrent diabetic gastroparesis when dosed four times a day for 28 days. Henry P. Parkman, M.D., Director of the GI Motility Laboratory at the Temple University School of Medicine, will be presenting the data at DDW on Saturday, May 3, 2014. Dr. Parkman commented, "The results of this large Phase 2b clinical trial were encouraging and quite unexpected. In this large study, metoclopramide nasal spray provided a significant clinical benefit in reducing the symptoms of diabetic gastroparesis in women, while in men, it did not. Since more than 80% of patients with diabetic gastroparesis are female, this is important new information that I look forward to presenting at this year's Digestive Disease Week. Metoclopramide nasal spray has the potential to address an unmet need for patients who are suffering from this disease." Marilyn R. Carlson, D.M.D., M.D., Chief Medical Officer of Evoke, added, "One of the major challenges in treating patients with gastroparesis is to ensure adequate drug absorption even when they are experiencing symptom flares. EVK-001 delivers metoclopramide as a nasal spray which may provide predictable absorption regardless of symptoms and gastric emptying delays. These Phase 2b data represent an important step in addressing the need for more effective management of symptoms for women with diabetic gastroparesis. We believe Digestive Disease Week is an excellent forum through which to present these clinical research findings to scientists and physicians."