Ironwood and Forest Announce FDA Approval of LINZESSTM

Ironwood Pharmaceuticals, Inc.

and Forest Laboratories, Inc.

announced today that LINZESS™ (linaclotide) was approved by the U.S. Food and Drug Administration (FDA) as a once-daily treatment for adult men and women suffering from irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). IBS-C and CIC are chronic functional gastrointestinal disorders that affect as many as 13 million1 and 35 million2 adult Americans, respectively. Symptoms associated with IBS-C include abdominal pain and constipation; symptoms associated with CIC include constipation (infrequent stools, hard stools and incomplete evacuation). There are few treatment options for these conditions, particularly options that relieve abdominal pain associated with IBS-C.