Precigen Touts Encouraging Data From Autologous UltraCAR-T Cells Manufactured Overnight For Next Day Infusion In Ovarian Cancer

  • Precigen Inc PGEN presented data at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting from the Phase 1 portion of the Phase 1/1b study of PRGN-3005 UltraCAR-T in advanced-stage platinum-resistant ovarian cancer patients.
  • The company says that patients in the IV plus lymphodepletion arm showed stable or partial response in 90% of the individual target lesions. The case study demonstrated that repeat dosing further decreased tumor burden. 
  • Also Read: Precigen Regains Rights To CAR-T Platform For Hematological, Solid Tumor Indications.
  • PRGN-3005 was well-tolerated with a low incidence of treatment-related adverse events (TRAEs), no dose-limiting toxicities (DLTs), and no neurotoxicity. 
  • PRGN-3005, administered intraperitoneally or intravenously at doses as low as 2 million CAR-T cells, showed a dose-dependent expansion and encouraging persistence in peripheral blood.
  • Best responder achieved stable disease for more than 18 months after failing nine prior lines of treatment; results were achieved with two doses of UltraCAR-T cells in the low millions.
  • Incorporating lymphodepletion before IV infusion led to an efficacy signal as demonstrated by a decrease in tumor burden in 67% (6/9) of patients, with concurrent decreases in CA125 at Day 35 in 89% (8/9) of patients and stable or partial response in 90% of the individual target lesions.
  • PRGN-3005 UltraCAR-T cells are currently being evaluated in the Phase 1b dose expansion study at Dose Level 3 via IV infusion with lymphodepletion and incorporating repeat dosing.
  • Price Action: PGEN shares closed at $1.34 on Monday.
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