AstraZeneca Highlights First Results From Datopotamab Study In Pretreated Breast Cancer Patients

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  • AstraZeneca Plc AZN reported initial data from the TROPION-PanTumor01 Phase 1 trial of datopotamab deruxtecan (Dato-DXd).
  • The data showed encouraging and durable efficacy in patients with heavily pretreated hormone receptor (HR)-positive, HER2-low, or HER2-negative (IHC 0) unresectable or metastatic breast cancer. 
  • Safety results were consistent with previous trials of datopotamab deruxtecan. 
  • Also see: AstraZeneca Highlights Detailed Data From Two Breast Cancer Trials.
  • In this cohort of TROPION-PanTumor01 (n=41), datopotamab deruxtecan demonstrated an objective response rate (ORR) of 27%. 
  • All responses were partial (n=11), and 56% of patients achieved stable disease (n=23). 
  • The disease control rate (DCR) was 85%, and the median progression-free survival (PFS) was 8.3 months. 
  • With a median follow-up of 13.7 months, the median duration of response (DoR) and the median overall survival (OS) had not been reached, with 59% of patients alive for more than one year.
  • Pivotal TROPION-Breast01 Phase 3 trial is ongoing, evaluating datopotamab deruxtecan in these patients in earlier lines of treatment.
  • Datopotamab deruxtecan is a specifically engineered TROP2-directed DXd antibody-drug conjugate (ADC) jointly developed by Daiichi Sankyo DSNKY and AstraZeneca.
  • Price Action: AZN shares closed higher by 0.46% at $69.17 on Thursday.
  • Photo Via Wikimedia Commons
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